⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9019150 | 1.00 | — | — | |
| SCHEMBL9018986 | 1.00 | — | — | |
| SCHEMBL9755036 | 0.78 | — | — | |
| SCHEMBL9019005 | 0.77 | THRB (0.35) | — | |
| SCHEMBL9019002 | 0.77 | THRB (0.35) | — | |
| SCHEMBL3673885 | 0.76 | — | — | |
| SCHEMBL9019000 | 0.75 | — | — | |
| SCHEMBL9019024 | 0.75 | — | — | |
| SCHEMBL11223116 | 0.70 | — | — | |
| SCHEMBL3663645 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9492553-B2 | Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods | GENENTECH, INC. (US) | 2016-11-15 | — | — | US | disclosed |
| US-9492553-B2 | Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods | GENENTECH, INC. (US) | 2016-11-15 | — | — | US | disclosed |
| EP-2240495-B1 | NEMORUBICIN METABOLITE AND ANALOG REAGENTS, ANTIBODY-DRUG CONJUGATES AND METHODS | GENENTECH INC (US) | 2015-07-15 | — | — | EP | disclosed |
| US-20140227299-A1 | NEMORUBICIN METABOLITE AND ANALOG REAGENTS, ANTIBODY-DRUG CONJUGATES AND METHODS | GENENTECH, INC. (US) | 2014-08-14 | — | — | US | disclosed |
| US-20140227299-A1 | NEMORUBICIN METABOLITE AND ANALOG REAGENTS, ANTIBODY-DRUG CONJUGATES AND METHODS | GENENTECH, INC. (US) | 2014-08-14 | — | — | US | disclosed |
| US-8742076-B2 | Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods | GENENTECH, INC. (US) | 2014-06-03 | — | — | US | disclosed |
| US-8742076-B2 | Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods | GENENTECH, INC. (US) | 2014-06-03 | — | — | US | disclosed |
| US-20110076287-A1 | NEMORUBICIN METABOLITE AND ANALOG REAGENTS, ANTIBODY-DRUG CONJUGATES AND METHODS | GENENTECH, INC. | 2011-03-31 | — | — | US | disclosed |
| US-20110076287-A1 | NEMORUBICIN METABOLITE AND ANALOG REAGENTS, ANTIBODY-DRUG CONJUGATES AND METHODS | GENENTECH, INC. | 2011-03-31 | — | — | US | disclosed |
| EP-2240495-A1 | NEMORUBICIN METABOLITE AND ANALOG REAGENTS, ANTIBODY-DRUG CONJUGATES AND METHODS | Genentech, Inc. (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009099741-A1 | NEMORUBICIN METABOLITE AND ANALOG REAGENTS, ANTIBODY-DRUG CONJUGATES AND METHODS | GENENTECH, INC. (US) | 2009-08-13 | — | — | WO | disclosed |
| EP-0434960-B1 | Chiral 1,5-diiodo-2-methoxy or benzyloxy intermediates | PHARMACIA SPA (IT) | 1996-09-18 | — | — | EP | disclosed |
| US-5304687-A | 1-alkoxy-2,2*-diiodo-diethyl ether which reacts with doxorubicin to yield anthrocycline antibiotics | FARMITALIA CARLO ERBA S.R.L. (IT) | 1994-04-19 | — | — | US | disclosed |
| EP-0434960-A1 | Chiral 1,5-diiodo-2-methoxy or benzyloxy intermediates | PHARMACIA S.p.A. (IT) | 1991-07-03 | — | — | EP | disclosed |
| WO-1991009046-A1 | MORPHOLINYL DERIVATIVES OF DOXORUBICIN AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1991-06-27 | — | — | WO | disclosed |