Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.63 |
| ▸ | GAA | P10253 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3508652 | 0.88 | IKBKB (0.67) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL10052251 | 0.83 | IKBKB (0.57) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL3677871 | 0.80 | TSHR (0.44) | IKBKBMEN1KMT2ACHEK1JAK2 | |
| SCHEMBL3507771 | 0.80 | IKBKB (0.73) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL1428734 | 0.79 | IKBKB (0.58) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL1428022 | 0.78 | IKBKB (0.71) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL1428039 | 0.78 | IKBKB (0.71) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL5898698 | 0.78 | IKBKB (0.71) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL3512558 | 0.78 | IKBKB (0.57) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL3510525 | 0.78 | IKBKB (1.00) | IKBKBGAAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |