Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 4/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3673887 | 0.80 | IKBKB (0.63) | IKBKBCHEK1JAK2MEN1EIF2AK2 | |
| SCHEMBL3511240 | 0.79 | MAPK1 (0.44) | TSHRIKBKBCHEK1JAK2MEN1 | |
| SCHEMBL3512115 | 0.78 | JAK2 (0.47) | IKBKBCHEK1JAK2MEN1EIF2AK2 | |
| SCHEMBL3508888 | 0.77 | IKBKB (0.40) | IKBKBCHEK1JAK2MEN1EIF2AK2 | |
| SCHEMBL3508956 | 0.74 | CASP1 (0.41) | IKBKBCHEK1JAK2MEN1EIF2AK2 | |
| SCHEMBL3509176 | 0.73 | IKBKB (0.36) | IKBKBCHEK1JAK2MEN1EIF2AK2 | |
| SCHEMBL3509073 | 0.72 | IKBKB (0.37) | IKBKBCHEK1JAK2MEN1EIF2AK2 | |
| SCHEMBL3507361 | 0.72 | JAK2 (0.37) | IKBKBCHEK1JAK2MEN1EIF2AK2 | |
| SCHEMBL3509187 | 0.72 | JAK2 (0.41) | IKBKBCHEK1JAK2MEN1EIF2AK2 | |
| SCHEMBL3509183 | 0.72 | JAK2 (0.41) | IKBKBCHEK1JAK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |