Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 7/20 | 0.62 |
| ▸ | BCL2 | P10415 | 2/20 | 0.62 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.62 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.60 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | PPARD | Q03181 | 1/20 | 0.53 |
| ▸ | PPARA | Q07869 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1180094 | 0.89 | BCL2 (0.54) | MRGPRX4BCL2MCL1NR1H4PPARD | |
| SCHEMBL29941673 | 0.87 | PLAU (0.71) | — | |
| SCHEMBL3193186 | 0.85 | MAPK14 (0.61) | RAB9APPARDPPARA | |
| SCHEMBL6100496 | 0.82 | ALOX5 (0.61) | MRGPRX4RAB9APPARDPPARA | |
| SCHEMBL6193094 | 0.81 | PLA2G10 (0.57) | — | |
| SCHEMBL2275593 | 0.81 | PLAU (0.57) | BCL2MCL1NR1H4 | |
| SCHEMBL3862821 | 0.81 | PPARD (0.72) | PPARDPPARA | |
| SCHEMBL2270794 | 0.81 | MRGPRX4 (0.64) | MRGPRX4BCL2MCL1NR1H4NR4A2 | |
| SCHEMBL2828419 | 0.80 | FFAR1 (0.63) | PPARDPPARA | |
| SCHEMBL6086123 | 0.80 | MAPK14 (0.54) | BCL2MCL1RAB9APPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173174-A1 | FARNESOID X RECEPTOR AGONISTS | GlaxoSmithKline LLC (US) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009005998-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |