Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR2 | P30874 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 4/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL841410 | 0.99 | SSTR2 (0.40) | SSTR2SCN9AKCNH2SCN5APDCD1 | |
| Ammonia Solution, Strong SCHEMBL3674494 | 0.82 | SCN5A (0.37) | SCN9AKCNH2SCN5AGRM5GRM1 | |
| SCHEMBL841203 | 0.81 | SCN9A (0.46) | SCN9AKCNH2SCN5A | |
| SCHEMBL841364 | 0.81 | SCN5A (0.38) | SCN9AKCNH2SCN5AGRM5GRM1 | |
| SCHEMBL3674446 | 0.81 | IDO1 (0.38) | SSTR2PDCD1CD274PDE3BPDE3A | |
| Ammonia Solution, Strong SCHEMBL3668899 | 0.80 | SCN9A (0.49) | SCN9AKCNH2SCN5A | |
| Ammonia Solution, Strong SCHEMBL3676946 | 0.79 | SCN9A (0.46) | SCN9AKCNH2SCN5A | |
| SCHEMBL841025 | 0.79 | SCN9A (0.49) | SCN9AKCNH2SCN5A | |
| Ammonia Solution, Strong SCHEMBL3668936 | 0.78 | ELANE (0.37) | USP30 | |
| SCHEMBL839937 | 0.78 | SCN9A (0.47) | SCN9AKCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158198-A2 | NOVEL N- (8HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008130320-A2 | NOVEL N- (8-HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |