Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 4/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 3/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.34 |
| ▸ | EED | O75530 | 1/20 | 0.33 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.33 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL841364 | 0.99 | SCN5A (0.38) | SCN5ASCN9AKCNH2ADORA2BBACE1 | |
| Ammonia Solution, Strong SCHEMBL3674445 | 0.82 | SSTR2 (0.39) | SCN5ASCN9AKCNH2IDO1GRM5 | |
| Ammonia Solution, Strong SCHEMBL3676946 | 0.82 | SCN9A (0.46) | SCN5ASCN9AKCNH2 | |
| SCHEMBL841410 | 0.81 | SSTR2 (0.40) | SCN5ASCN9AKCNH2IDO1GRM5 | |
| SCHEMBL839937 | 0.80 | SCN9A (0.47) | SCN5ASCN9AKCNH2 | |
| SCHEMBL841223 | 0.80 | SCN5A (0.38) | SCN5ASCN9AKCNH2GRM5 | |
| SCHEMBL3674498 | 0.79 | DPP4 (0.40) | ADORA2BBACE1CTSDPARP10PARP11 | |
| SCHEMBL839693 | 0.77 | SCN9A (0.38) | SCN5ASCN9AKCNH2 | |
| SCHEMBL839932 | 0.76 | SCN9A (0.38) | SCN5ASCN9AKCNH2BACE1 | |
| Ammonia Solution, Strong SCHEMBL3672811 | 0.76 | SCN9A (0.46) | SCN5ASCN9AKCNH2EEDSUZ12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158198-A2 | NOVEL N- (8HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008130320-A2 | NOVEL N- (8-HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |