Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 12/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ACACA | Q13085 | 10/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.32 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3677156 | 0.87 | HCRTR1 (0.40) | ACACBKDM4EPKMACACAACKR3 | |
| SCHEMBL496419 | 0.86 | HIF1A (0.38) | KDM4EPKMACKR3 | |
| SCHEMBL3641052 | 0.83 | ACKR3 (0.36) | ACACBKDM4EPKMACACAACKR3 | |
| SCHEMBL496426 | 0.81 | KDM4E (0.41) | KDM4E | |
| SCHEMBL2442561 | 0.81 | KDM4E (0.41) | KDM4E | |
| SCHEMBL496277 | 0.81 | TP53 (0.39) | ACKR3 | |
| SCHEMBL496193 | 0.78 | GAA (0.35) | ACACBMEN1KMT2A | |
| SCHEMBL3674486 | 0.75 | HCRTR1 (0.50) | — | |
| SCHEMBL496423 | 0.75 | NR1H2 (0.34) | NAMPT | |
| SCHEMBL496719 | 0.75 | HTR4 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164847-A1 | 3-AZA-BICYCLO[3.3.0]OCTANE COMPOUNDS | Actelion Pharmaceuticals Ltd. (CH) | 2010-03-24 | — | — | EP | disclosed |
| WO-2009004584-A1 | 3-AZA-BICYCLO[3.3.0]OCTANE COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-01-08 | — | — | WO | disclosed |