⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10136171 | 1.00 | — | — | |
| SCHEMBL2091941 | 1.00 | — | — | |
| SCHEMBL9136125 | 0.75 | — | — | |
| SCHEMBL14099211 | 0.67 | — | — | |
| SCHEMBL22638827 | 0.62 | — | — | |
| SCHEMBL3063199 | 0.61 | EGLN1 (0.42) | — | |
| SCHEMBL9497593 | 0.60 | — | — | |
| SCHEMBL7988956 | 0.57 | — | — | |
| SCHEMBL1640394 | 0.57 | — | — | |
| SCHEMBL6140149 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115551867-B | Fused tricyclic compounds, pharmaceutical compositions and uses thereof | 劲方医药科技(上海)有限公司 | 2024-02-20 | — | — | CN | claimed |
| CN-112441961-B | Synthetic method of 3-pyrroline-2-ketone compound | 浙江工业大学 | 2022-03-18 | — | — | CN | claimed |
| CN-109232357-B | Method for catalytically synthesizing 3-pyrroline-2-ketone in emulsion by titanocene dichloride in cooperation with Bronsted acid | 陕西师范大学 | 2021-10-01 | — | — | CN | claimed |
| CN-112694430-A | Preparation method of 1, 5-dihydro-2H-pyrrole-2-ketone compound | 浙江理工大学 | 2021-04-23 | — | — | CN | claimed |
| CN-112441961-A | Synthetic method of 3-pyrroline-2-ketone compound | 浙江工业大学 | 2021-03-05 | — | — | CN | claimed |
| EP-1915149-B1 | NOVEL TRIAZOLE DERIVATIVES AS GHRELIN ANALOGUE LIGANDS OF GROWTH HORMONE SECRETAGOGUE RECEPTORS | AETERNA ZENTARIS GMBH (DE) | 2018-10-10 | — | — | EP | claimed |
| CN-106008304-B | A kind of 1,3- pyrrolin -2- ketone compounds and its synthetic method | 湖北科技学院 | 2018-07-17 | — | — | CN | claimed |
| CN-107434777-A | The synthesis of the ketone derivatives of 1,5 dihydro 2H pyrroles 2 and antitumor action | 重庆文理学院 | 2017-12-05 | — | — | CN | claimed |
| US-8710089-B2 | Triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors | ZENTARIS GMBH (DE) | 2014-04-29 | — | — | US | claimed |
| US-20100331343-A1 | NOVEL TRIAZOLE DERIVATIVES AS GHRELIN ANALOGUE LIGANDS OF GROWTH HORMONE SECRETAGOGUE RECEPTORS | ZENTARIS GMBH (DE) | 2010-12-30 | — | — | US | claimed |
| US-20090042905-A1 | TRIAZOLE DERIVATIVES AS LIGANDS OF G-PROTEIN COUPLED RECEPTORS | AETERNA ZENTARIS GMBH (DE) | 2009-02-12 | — | — | US | claimed |
| US-20070208061-A2 | NOVEL TRIAZOLE DERIVATIVES AS GHRELIN ANALOGUE LIGANDS OF GROWTH HORMONE SECRETAGOGUE RECEPTORS | ZENTARIS GMBH (DE) | 2007-09-06 | — | — | US | claimed |
| US-20070037857-A1 | Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors | ZENTARIS GMBH (DE) | 2007-02-15 | — | — | US | claimed |
| CN-112694430-B | Preparation method of 1, 5-dihydro-2H-pyrrole-2-ketone compound | 浙江理工大学 | 2022-10-04 | — | — | CN | disclosed |
| CN-112694430-B | Preparation method of 1, 5-dihydro-2H-pyrrole-2-ketone compound | 浙江理工大学 | 2022-10-04 | — | — | CN | disclosed |
| CN-112694430-B | Preparation method of 1, 5-dihydro-2H-pyrrole-2-ketone compound | 浙江理工大学 | 2022-10-04 | — | — | CN | disclosed |
| US-7476657-B2 | Peptides and peptidomimetics having anti-proliferative activity and/or that augment nucleic acid damaging agents or treatments | TAKEDA PHAMACEUTICAL COMPANY LIMITED (JP) | 2009-01-13 | — | — | US | disclosed |
| EP-1958631-A1 | Novel triazole derivatives as ligands of G-protein coupled receptors | AEterna Zentaris GmbH (DE) | 2008-08-20 | — | — | EP | disclosed |
| US-20070208061-A2 | NOVEL TRIAZOLE DERIVATIVES AS GHRELIN ANALOGUE LIGANDS OF GROWTH HORMONE SECRETAGOGUE RECEPTORS | ZENTARIS GMBH (DE) | 2007-09-06 | — | — | US | disclosed |
| US-20070037857-A1 | Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors | ZENTARIS GMBH (DE) | 2007-02-15 | — | — | US | disclosed |