Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16640388 | 0.83 | GSK3B (0.46) | GSK3BPRKCQPRKCD | |
| SCHEMBL16640395 | 0.81 | SLC6A9 (0.50) | GSK3BPRKCQ | |
| SCHEMBL16640384 | 0.79 | GSK3B (0.47) | GSK3BKDM4EDRD2DRD4 | |
| SCHEMBL16640383 | 0.79 | GSK3B (0.49) | GSK3BKMT2AKDM4EDRD2DRD4 | |
| SCHEMBL1743174 | 0.74 | KDM4E (0.40) | KMT2AKDM4ELMNAL3MBTL1 | |
| SCHEMBL16640441 | 0.73 | SLC6A9 (0.48) | GSK3B | |
| SCHEMBL16640424 | 0.73 | SLC6A9 (0.48) | GSK3B | |
| SCHEMBL16640387 | 0.73 | SLC6A9 (0.48) | GSK3B | |
| SCHEMBL21105412 | 0.73 | SLC6A9 (0.48) | GSK3B | |
| SCHEMBL15930710 | 0.73 | PRKCQ (0.57) | GSK3BPRKCQPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155717-A1 | 2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008141020-A1 | 2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2008-11-20 | — | — | WO | disclosed |