Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 8/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL602110 | 0.86 | CYP19A1 (0.43) | CES2MAPTLMNATSHRKMT2A | |
| SCHEMBL10240260 | 0.77 | ESR2 (0.44) | CES2MAPTLMNATSHRKMT2A | |
| SCHEMBL4354633 | 0.75 | ALDH1A1 (0.41) | MAPTLMNATSHRKMT2ARXRA | |
| SCHEMBL3672218 | 0.73 | ESR2 (0.51) | MAPTPDE5ALMNAP2RY14 | |
| SCHEMBL20437077 | 0.73 | CA12 (0.47) | MAPTLMNACA12CA1CA2 | |
| SCHEMBL24351674 | 0.72 | TSHR (0.47) | CES2MAPTLMNATSHR | |
| SCHEMBL10188595 | 0.71 | NPC1 (0.42) | MAPTPDE5ALMNAP2RY14KMT2A | |
| SCHEMBL24293935 | 0.71 | ESR2 (0.42) | MAPTKMT2ACA12CA1CA2 | |
| SCHEMBL600832 | 0.71 | NPC1 (0.42) | MAPTPDE5ALMNAP2RY14KMT2A | |
| SCHEMBL9810320 | 0.70 | CA1 (0.44) | MAPTLMNAKMT2ACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391611-B1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-04-30 | — | — | EP | disclosed |
| EP-2391611-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010086551-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-08-05 | — | — | WO | disclosed |