SCHEMBL3675170

O=C(Nc1nn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c2ccc(Cc3cc(F)cc(F)c3)cc12)c1cc(C(=O)N2CCC[C@H]2CN2CCCC2)ccc1F.O=C(O)c1ccc(F)c(C(=O)Nc2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3ccc(Cc4cc(F)cc(F)c4)cc23)c1

nearest known ligand 0.36

Predicted protein targets (top 7)

	gene	UniProt	supporting neighbours	confidence
▸	ATR	Q13535	1/20	0.36

▸	ALK	Q9UM73	7/20	0.36

▸	INSR	P06213	3/20	0.36

▸	IGF1R	P08069	1/20	0.36

▸	HRH3	Q9Y5N1	6/20	0.35

▸	MET	P08581	4/20	0.35

▸	KCNH2	Q12809	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL3675174	1.00	ATR (0.36)	ATRALKINSRIGF1RHRH3
SCHEMBL3512603	0.98	ATR (0.37)	ATRALKINSRIGF1RHRH3
SCHEMBL3512606	0.98	ATR (0.37)	ATRALKINSRIGF1RHRH3
SCHEMBL3675173	0.88	MET (0.33)	ATRALKINSRIGF1RHRH3
SCHEMBL3513451	0.86	ALK (0.39)	ALKINSRIGF1R
SCHEMBL3513453	0.80	ALK (0.40)	ALKINSRIGF1R
SCHEMBL3512848	0.79	ALK (0.56)	ALKINSRIGF1RMET
SCHEMBL3512844	0.79	ALK (0.56)	ALKINSRIGF1RMET
SCHEMBL3514487	0.79	ALK (0.56)	ALKINSRIGF1RMET
SCHEMBL3513992	0.76	ALK (0.38)	ALKINSRIGF1RMET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2176231-A1	SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS	Nerviano Medical Sciences S.r.l. (IT)	2010-04-21	—	—	EP	disclosed
WO-2009013126-A1	SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS	NERVIANO MEDICAL SCIENCES S.R.L. (IT)	2009-01-29	—	—	WO	disclosed