SCHEMBL3675463

SCHEMBL3675463

O=C(Nc1cccc(Cl)c1)c1cccc(Cl)c1

nearest known ligand 0.84

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KCNK3 O14649 2/20 0.84
KCNK9 Q9NPC2 2/20 0.84
NPC1 O15118 2/20 0.83
RAB9A P51151 2/20 0.83
SMN1; SMN2 Q16637 1/20 0.71
MEN1 O00255 2/20 0.70
KMT2A Q03164 2/20 0.70
KCNQ3 O43525 1/20 0.69
KCNQ2 O43526 1/20 0.69
KCNE1 P15382 1/20 0.69
KCNQ1 P51787 1/20 0.69
KCNQ5 Q9NR82 1/20 0.69
LMNA P02545 2/20 0.67
PTBP1 P26599 1/20 0.67
ALDH1A1 P00352 1/20 0.67
MAPT P10636 1/20 0.67
HTT P42858 1/20 0.67
RXFP1 Q9HBX9 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3786882 0.91 KCNK3 (0.87) KCNK3KCNK9NPC1RAB9AMEN1
SCHEMBL3794687 0.91 NPC1 (1.00) KCNK3KCNK9NPC1RAB9ASMN1; SMN2
SCHEMBL1811760 0.90 KCNK3 (0.79) KCNK3KCNK9NPC1RAB9AMEN1
SCHEMBL2107465 0.90 KCNK3 (0.74) KCNK3KCNK9NPC1RAB9ASMN1; SMN2
Iodide SCHEMBL30758613 0.89 NPC1 (0.97) KCNK3KCNK9NPC1RAB9ASMN1; SMN2
SCHEMBL24118808 0.89 NPC1 (0.71) KCNK3KCNK9NPC1RAB9ASMN1; SMN2
Hydrochloric Acid SCHEMBL2107467 0.89 KCNK3 (0.77) KCNK3KCNK9NPC1RAB9AMEN1
SCHEMBL5353587 0.89 KCNK3 (0.72) KCNK3KCNK9NPC1RAB9ASMN1; SMN2
SCHEMBL1355422 0.89 NPC1 (0.71) KCNK3KCNK9NPC1RAB9ASMN1; SMN2
SCHEMBL4247170 0.89 KCNK3 (0.91) KCNK3KCNK9NPC1RAB9AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1329444-B1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR CORP (JP) 2010-05-05 EP disclosed
US-6933068-B2 Polymer electrolyte membrane and solid polymer electrolyte fuel cell using same HONDA GIKEN KOGYO KABUSHIKI KAISHA (JP) 2005-08-23 US disclosed
EP-1245554-B1 Monomer containing electron-withdrawing group and electron-donative group, and copolymer and proton-conductive membrane comprising same JSR CORP (JP) 2005-01-26 EP disclosed
US-6833426-B2 A proton-conductive membrane containing the sulfonic acid group-containing polyarylene (co)polymer JSR CORPORATION (JP) 2004-12-21 US disclosed
US-6794480-B2 POLYARYLENE-BASED COPOLYMER USEFUL AS PROTON-CONDUCTIVE MEMBRANE WHICH CAN BE USED AS ELECTRON FOR PRIMARY BATTERY, ELECTROLYTE FOR SECONDARY BATTERY, HIGH MOLECULAR SOLID ELECTROLYTE FOR FUEL CELL JSR CORPORATION (JP) 2004-09-21 US disclosed
US-20030173547-A1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR CORPORATION (JP) 2003-09-18 US disclosed
EP-1329444-A1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR Corporation (JP) 2003-07-23 EP disclosed
US-20020177656-A1 Monomer containing electron-withdrawing group and electron-donative group, and copolymer and proton-conductive membrane comprising same JSR CORPORATION (JP) 2002-11-28 US disclosed
US-20020172850-A1 Polymer electrolyte membrane and solid polymer electrolyte fuel cell using same HONDA GIKEN KOGYO KABUSHIKI KAISHA, JSR CORPORATION 2002-11-21 US disclosed
EP-0773249-B1 Polyphenylene co-polymers MISSISSIPPI POLYMER TECHNOLOGI (US) 2002-10-02 EP disclosed
EP-1245554-A1 Monomer containing electron-withdrawing group and electron-donative group, and copolymer and proton-conductive membrane comprising same JSR Corporation (JP) 2002-10-02 EP disclosed
US-5886130-A THE CO-POLYMERS ARE USEFUL AS MOLDING RESINS, AND COMPOSITE MATRIX RESINS, AND WHERE AR IS HETEROARYLENE AS ION EXCHANGE RESINS. MAXDEM INCORPORATED (US) 1999-03-23 US disclosed
EP-0596406-B1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 1998-12-16 EP disclosed
US-5750699-A HALOGENATING OF CORRESPONDING COMPOUND FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-05-12 US disclosed
EP-0773249-A1 Polyphenylene co-polymers MAXDEM INCORPORATED (US) 1997-05-14 EP disclosed
US-5574042-A ANTAGONIST FOR BRADYKININS AS ANTIALLERGENS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, SHOCK OR PAIN FUJISAWA PHARMACEUTICAL CO., LTD (JP) 1996-11-12 US disclosed
EP-0596406-A1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-05-11 EP disclosed
US-4499167-A Photoconductive compositions comprising an organic photoconductor and an amide compound and electro-photographic light-sensitive materials using the compositions FUJI PHOTO FILM CO., LTD. (JP) 1985-02-12 US disclosed