Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phentermine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.95 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.95 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | GHSR | Q92847 | 2/20 | 0.42 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phentermine SCHEMBL10392295 | 0.97 | SLC6A2 (1.00) | SLC6A2TAAR1SLC6A4SLC6A3HTR2A | |
| Phentermine SCHEMBL26615 | 0.97 | SLC6A2 (1.00) | SLC6A2TAAR1SLC6A4SLC6A3HTR2A | |
| Phentermine SCHEMBL28729624 | 0.95 | SLC6A2 (0.95) | SLC6A2TAAR1SLC6A4SLC6A3HTR2A | |
| Phentermine SCHEMBL41585 | 0.95 | SLC6A2 (0.95) | SLC6A2TAAR1SLC6A4SLC6A3HTR2A | |
| Phentermine SCHEMBL28695767 | 0.95 | SLC6A2 (0.95) | SLC6A2TAAR1SLC6A4SLC6A3HTR2A | |
| Phentermine SCHEMBL25214698 | 0.93 | SLC6A2 (0.91) | SLC6A2TAAR1SLC6A4SLC6A3HTR2A | |
| Phentermine SCHEMBL29261099 | 0.93 | SLC6A2 (0.91) | SLC6A2TAAR1SLC6A4SLC6A3HTR2A | |
| Phentermine SCHEMBL677133 | 0.93 | SLC6A2 (0.91) | SLC6A2TAAR1SLC6A4SLC6A3HTR2A | |
| SCHEMBL11709671 | 0.89 | SLC6A2 (0.83) | SLC6A2TAAR1SLC6A4SLC6A3HTR2A | |
| Phentermine SCHEMBL11072448 | 0.87 | SLC6A2 (0.79) | SLC6A2TAAR1SLC6A4SLC6A3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7659256-B2 | Combination therapy for effecting weight loss and treating obesity | VIVUS, INC. (US) | 2010-02-09 | — | — | US | claimed |
| WO-2023098691-A1 | ANTIBODY-DRUG CONJUGATE AND USE THEREOF | 上海生物制品研究所有限责任公司 | 2023-06-08 | — | — | WO | disclosed |
| CN-114711138-A | Preparation and application method of product for improving pollination rate of crops to achieve improvement of grouting rate | 农纷集信息科技(江苏)有限公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-113234081-A | Preparation method of pyrrolopyrazole derivative and DMDPEDA as urea | 东南大学 | 2021-08-10 | — | — | CN | disclosed |
| CN-113040049-A | Preparation and application method of product for improving pollination rate of crops to achieve improvement of grouting rate | 农纷集信息科技(江苏)有限公司 | 2021-06-29 | — | — | CN | disclosed |