Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 9/20 | 0.54 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.54 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.54 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.54 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.54 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 2/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3197182 | 0.80 | ACVRL1 (0.47) | ACVRL1BMPR1BBMPR1AACVR1BTGFBR1 | |
| SCHEMBL3204033 | 0.76 | ACVRL1 (0.43) | ACVRL1BMPR1BBMPR1AACVR1BTGFBR1 | |
| SCHEMBL4029987 | 0.72 | ACVRL1 (0.52) | ACVRL1NPC1RAB9APOLBCASP3 | |
| SCHEMBL24469661 | 0.72 | ACVRL1 (0.42) | ACVRL1BMPR1BBMPR1AACVR1BTGFBR1 | |
| SCHEMBL24469499 | 0.72 | ACVRL1 (0.38) | ACVRL1BMPR1BBMPR1AACVR1BTGFBR1 | |
| SCHEMBL30374878 | 0.69 | ATR (0.43) | ACVRL1BMPR1BBMPR1AACVR1BTGFBR1 | |
| SCHEMBL21596957 | 0.69 | ATR (0.43) | ACVRL1BMPR1BBMPR1AACVR1BTGFBR1 | |
| SCHEMBL3668157 | 0.69 | ACVRL1 (0.39) | ACVRL1BMPR1BBMPR1AACVR1BTGFBR1 | |
| SCHEMBL3203728 | 0.68 | ACVRL1 (0.38) | ACVRL1BMPR1BBMPR1AACVR1BTGFBR1 | |
| SCHEMBL29607098 | 0.68 | ACVRL1 (0.38) | ACVRL1BMPR1BBMPR1AACVR1BTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562612-B1 | COMBINATION PRODUCT OF INHIBITOR OF THE SRC FAMILY OF NON-RECEPTOR TYROSINE KINASES AND GEMCITABINE FOR USE IN THE TREATMENT OR PROPHLAXIX OF PANCREATIC CANCER | ASTRAZENECA AB (SE) | 2010-01-27 | — | — | EP | disclosed |
| EP-1562955-B1 | QUINAZOLINE DERIVATIVES AS SRC TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-02-27 | — | — | EP | disclosed |