SCHEMBL3677488

SCHEMBL3677488

NCC(=O)Nc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.71

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.65
KMT2A Q03164 5/20 0.65
MAPT P10636 5/20 0.59
ALDH1A1 P00352 4/20 0.59
LMNA P02545 3/20 0.59
HTT P42858 3/20 0.59
POLB P06746 3/20 0.58
HSP90AA1 P07900 1/20 0.57
CA1 P00915 1/20 0.57
CA2 P00918 1/20 0.57
HPGD P15428 1/20 0.56
SMN1; SMN2 Q16637 1/20 0.56
TGM2 P21980 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4185047 0.98 MEN1 (0.62) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL13093172 0.91 MEN1 (0.71) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL30237583 0.89 ALDH1A1 (0.58) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL9018657 0.87 MEN1 (0.71) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL3262054 0.86 MEN1 (0.63) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL1263753 0.85 ALDH1A1 (0.59) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL23811 0.84 KMT2A (0.62) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL6053820 0.84 CA1 (0.52) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL7741358 0.84 MEN1 (0.67) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL4166954 0.82 MEN1 (0.65) MEN1KMT2AMAPTALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070059758-A1 Regulators of type-1 tumor necrosis factor receptor and other cytokine receptor shedding THE GOVERNMENT OF THE USA OF AMERICA, REP. BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2007-03-15 US claimed
US-20030215820-A1 Interleukins; aminopeptidases; blot analysis; drug screening GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2003-11-20 US claimed
US-6303360-B1 CULTURING SPHINGOMONAS; MOLECULAR HYBRIDIZATION; GENETIC ENGINEERING; HYDROLYZES ANILIDES OF ALANINE, GLYCINE, LEUCINE, GLUTAMIC ACID, ASPARTIC ACID, LYSINE, ISOLEUCINE, AND VALINE NOVOZYMES BIOTECH, INC, 2001-10-16 US claimed
WO-2001064856-A2 REGULATORS OF TYPE-1 TUMOR NECROSIS FACTOR RECEPTOR AND OTHER CYTOKINE RECEPTOR SHEDDING THE GOVERNMENT OF THE UNITED STATES OF AMERICA, A S REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEA LTH AND HUMAN SERVICES (US) 2001-09-07 WO claimed
US-6184020-B1 AMINO ACID AND NUCLEOTIDE SEQUENCE; FOR PRODUCTION OF PROTEIN HYDROLYSATES USED AS FLAVORINGS IN FOODS NOVO NORDISK BIOTECH, INC. 2001-02-06 US claimed
EP-0496680-B1 Procedure and medium to identify bacteria of the genus Listeria BIO MERIEUX (FR) 1995-09-06 EP claimed
US-5330889-A Colorimetric, fluorescence, enzymatic hydrolysis of substrate BIO MERIEUX (FR) 1994-07-19 US claimed
EP-0496680-A1 Procedure and medium to identify bacteria of the genus Listeria BIO MERIEUX, Société anonyme (FR) 1992-07-29 EP claimed
EP-3724328-B1 PEPTIDASE AND ITS USES CENTRE NAT RECH SCIENT (FR) 2025-08-20 EP disclosed
EP-4596689-A1 ENZYME AGENT AND USE THEREOF Amano Enzyme Inc. (JP) 2025-08-06 EP disclosed
CN-120092086-A Enzyme agent and application thereof 天野酶制品株式会社 2025-06-03 CN disclosed
CN-119874561-A Charged ion channel blockers and methods of use thereof 诺西恩医疗公司 2025-04-25 CN disclosed
CN-119546618-A Novel retinoic acid compounds, pharmaceutical compositions comprising the same and uses thereof 至善生医股份有限公司 2025-02-28 CN disclosed
EP-4489744-A1 PHARMACEUTICAL COMPOSITION INCLUDING RETINOIC ACID AND CARBOHYDRATE AND USE THEREOF Mastery Biotech Co., Ltd. (TW) 2025-01-15 EP disclosed
US-5330889-A Colorimetric, fluorescence, enzymatic hydrolysis of substrate BIO MERIEUX (FR) 1994-07-19 US disclosed
EP-0569380-A1 ACRIDINE DERIVATIVES. GLAXO LAB SA (FR) 1993-11-18 EP disclosed
EP-0496680-A1 Procedure and medium to identify bacteria of the genus Listeria BIO MERIEUX, Société anonyme (FR) 1992-07-29 EP disclosed
WO-1992012132-A1 ACRIDINE DERIVATIVES LABORATOIRES GLAXO S.A. (FR) 1992-07-23 WO disclosed
EP-0201811-A1 7-Oxabicycloheptane substituted aryl amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction E.R. Squibb & Sons, Inc. (US) 1986-11-20 EP disclosed
US-4607048-A 7-oxabicycloheptane substituted aryl amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction E. R. SQUIBB & SONS, INC. (US) 1986-08-19 US disclosed