Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Telcagepant. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL known ✓ | Q16602 | 20/20 | 0.97 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.97 |
| ▸ | CALCA | P06881 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Telcagepant SCHEMBL3678268 | 0.99 | CALCRL (0.99) | CALCRLRAMP1CALCA | |
| Telcagepant SCHEMBL3678042 | 0.99 | CALCRL (0.97) | CALCRLRAMP1CALCA | |
| Telcagepant SCHEMBL13345769 | 0.99 | CALCRL (1.00) | CALCRLRAMP1CALCA | |
| Telcagepant SCHEMBL3176473 | 0.99 | CALCRL (1.00) | CALCRLRAMP1CALCA | |
| Telcagepant SCHEMBL1198535 | 0.99 | CALCRL (1.00) | CALCRLRAMP1CALCA | |
| Telcagepant SCHEMBL32659727 | 0.99 | CALCRL (1.00) | CALCRLRAMP1CALCA | |
| Telcagepant SCHEMBL13025488 | 0.99 | CALCRL (1.00) | CALCRLRAMP1CALCA | |
| Telcagepant SCHEMBL29371277 | 0.99 | CALCRL (1.00) | CALCRLRAMP1CALCA | |
| Telcagepant SCHEMBL3678266 | 0.98 | CALCRL (0.99) | CALCRLRAMP1CALCA | |
| Telcagepant SCHEMBL3682410 | 0.95 | CALCRL (0.92) | CALCRLRAMP1CALCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100009967-A1 | SOLID DOSAGE FORMULATIONS OF TELCAGEPANT POTASSIUM | MERCK SHARP & DOHME CORP. | 2010-01-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009967-A1 | SOLID DOSAGE FORMULATIONS OF TELCAGEPANT POTASSIUM | KCNN1, KCNN2, KCNN3 | CALCRL 1126/4885RAMP1 2254/4885CALCA 2077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.