⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL882159 | 0.82 | — | — | |
| SCHEMBL1165180 | 0.82 | — | — | |
| SCHEMBL4251304 | 0.82 | TSHR (0.48) | — | |
| SCHEMBL8784853 | 0.76 | TSHR (0.42) | — | |
| SCHEMBL6882537 | 0.76 | TSHR (0.42) | — | |
| SCHEMBL10808355 | 0.76 | TSHR (0.48) | — | |
| SCHEMBL4585366 | 0.75 | TSHR (0.53) | — | |
| SCHEMBL28965299 | 0.75 | TSHR (0.53) | — | |
| SCHEMBL295903 | 0.75 | — | — | |
| SCHEMBL8924479 | 0.74 | TSHR (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102070497-B | Synthesis method of florfenicol | UNIV FUDAN | 2015-01-07 | — | — | CN | claimed |
| CN-102532368-B | Rare earth catalyst and method for polymerizing conjugated diene by using same | UNIV BEIJING CHEMICAL | 2014-04-02 | — | — | CN | claimed |
| CN-103420836-A | Purifying method of fluorine-containing low-carbon aliphatic acid | BIOTALK CO LTD | 2013-12-04 | — | — | CN | claimed |
| CN-102532368-A | Rare earth catalyst and method for polymerizing conjugated diene by using same | UNIV BEIJING CHEMICAL | 2012-07-04 | — | — | CN | claimed |
| CN-102070497-A | Synthesis method of florfenicol | UNIV FUDAN | 2011-05-25 | — | — | CN | claimed |
| CN-117903074-A | Preparation method of 4, 5-dihydro-isoxazole-3-carboxylic acid compound | 郑州手性药物研究院有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-112574113-A | Zoledronic acid intermediate compound | 鲁南制药集团股份有限公司 | 2021-03-30 | — | — | CN | disclosed |
| CN-102070497-B | Synthesis method of florfenicol | UNIV FUDAN | 2015-01-07 | — | — | CN | disclosed |
| CN-102532368-B | Rare earth catalyst and method for polymerizing conjugated diene by using same | UNIV BEIJING CHEMICAL | 2014-04-02 | — | — | CN | disclosed |
| CN-103420825-A | Synthetic method of difluoroacetate | BIOTALK CO LTD | 2013-12-04 | — | — | CN | disclosed |
| US-8293930-B1 | One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel | CHATHAM BIOTEC, LIMITED (CA) | 2012-10-23 | — | — | US | disclosed |
| CN-102532368-A | Rare earth catalyst and method for polymerizing conjugated diene by using same | UNIV BEIJING CHEMICAL | 2012-07-04 | — | — | CN | disclosed |
| US-20070032646-A1 | Novel taxanes and methods related to use and preparation thereof | INNOVATIONAL HOLDINGS LLC | 2007-02-08 | — | — | US | disclosed |
| US-20070027331-A1 | Semi-synthesis of taxane intermediates and aziridine analogues and their conversion to paclitaxel and docetaxel | INNOVATIONAL HOLDINGS LLC | 2007-02-01 | — | — | US | disclosed |
| US-20070027330-A1 | One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel | INNOVATIONAL HOLDINGS LLC | 2007-02-01 | — | — | US | disclosed |
| US-20070027207-A1 | Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel | INNOVATIONAL HOLDINGS LLC | 2007-02-01 | — | — | US | disclosed |
| US-20070027332-A1 | Semi-synthetic conversion of paclitaxel to docetaxel | INNOVATIONAL HOLDINGS LLC | 2007-02-01 | — | — | US | disclosed |
| EP-0279978-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING ALPHA-HALOGENATED DICARBOXYLIC ACIDS | Epis S.A. (CH) | 1992-01-02 | — | — | EP | disclosed |
| US-4908385-A | Pharmaceuticals | EPIS S.A. (CH) | 1990-03-13 | — | — | US | disclosed |
| EP-0279978-A1 | Pharmaceutical compositions containing alpha-halogenated dicarboxylic acids | Epis S.A. (CH) | 1988-08-31 | — | — | EP | disclosed |