Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | CCR4 | P51679 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.30 |
| ▸ | GCK | P35557 | 2/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL22518563 | 0.96 | CYP1A2 (0.37) | CYP1A2CYP2D6CYP2C9GRM1CSNK2A2 | |
| SCHEMBL313040 | 0.81 | CYP1A2 (0.38) | CYP1A2CYP2D6CYP2C9GRM1CSNK2A2 | |
| SCHEMBL2624132 | 0.79 | AURKA (0.39) | CYP1A2CYP2D6CYP2C9GRM1CSNK2A2 | |
| SCHEMBL20780324 | 0.73 | CCR4 (0.34) | CYP1A2CYP2D6CYP2C9GRM1TRPA1 | |
| Lithium Ion SCHEMBL20746311 | 0.71 | GRM5 (0.44) | PTGER1 | |
| Lithium Ion SCHEMBL31223897 | 0.71 | CSNK2A1 (0.35) | CSNK2A1PTGER1 | |
| Lithium Ion SCHEMBL31223893 | 0.71 | CSNK2A1 (0.35) | CSNK2A1PTGER1 | |
| Lithium Ion SCHEMBL3799858 | 0.66 | MAPT (0.47) | GAAPLATGCK | |
| SCHEMBL12190585 | 0.66 | L3MBTL1 (0.57) | CYP1A2CYP2D6CYP2C9GRM1CSNK2A2 | |
| SCHEMBL20780330 | 0.64 | CCR4 (0.36) | CYP1A2CYP2D6CYP2C9GRM1CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393493-A1 | COMPOUNDS | GlaxoSmithKline LLC (US) | 2011-12-14 | — | — | EP | disclosed |
| US-20100196321-A1 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-08-05 | — | — | US | disclosed |
| WO-2010088394-A1 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100196321-A1 | COMPOUNDS | HAVCR2, ACE, ACE2 | CYP1A2 51/4885CYP2D6 47/4885CYP2C9 152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.