Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 8/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.30 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL255618 | 0.85 | PDE10A (0.38) | PDE10AFGFR1FGFR2FGFR3MET | |
| SCHEMBL360598 | 0.85 | PDE10A (0.38) | PDE10AFGFR1FGFR3MET | |
| SCHEMBL359481 | 0.85 | EGFR (0.41) | PDE10AFGFR1FGFR2FGFR3MET | |
| SCHEMBL359817 | 0.85 | MET (0.40) | PDE10AFGFR1FGFR2FGFR3MET | |
| SCHEMBL178094 | 0.85 | MET (0.44) | FGFR1FGFR3MET | |
| SCHEMBL162668 | 0.85 | MET (0.43) | PDE10AMET | |
| SCHEMBL173298 | 0.84 | BRD4 (0.38) | PDE10AFGFR1FGFR2FGFR3MET | |
| SCHEMBL367903 | 0.84 | MET (0.40) | PDE10AFGFR1FGFR2FGFR3MET | |
| SCHEMBL360828 | 0.84 | MET (0.39) | PDE10AMETMCHR1 | |
| Hydrochloric Acid SCHEMBL174468 | 0.84 | PDE10A (0.37) | PDE10AFGFR1FGFR2FGFR3MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593107-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012009194-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | disclosed |