Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.46 |
| ▸ | ALB | P02768 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.46 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | POLG | P54098 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.39 |
| ▸ | IARS1 | P41252 | 1/20 | 0.39 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.38 |
| ▸ | P2RY4 | P51582 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3679791 | 1.00 | LMNA (0.46) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL4450498 | 0.95 | POLB (0.45) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL4450494 | 0.95 | POLB (0.45) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL3684936 | 0.92 | LMNA (0.48) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL13036649 | 0.92 | LMNA (0.48) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL3684934 | 0.92 | LMNA (0.48) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL4450475 | 0.87 | POLB (0.48) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL4450483 | 0.87 | POLB (0.48) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL13036661 | 0.86 | POLB (0.43) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL13036651 | 0.85 | LMNA (0.49) | LMNAPDE3ACACNA1FALBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7829548-B2 | Compounds useful in the treatment of HIV | MEDIVIR AB (SE) | 2010-11-09 | — | — | US | disclosed |
| EP-1835916-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF HIV | MEDIVIR AB (SE) | 2009-04-01 | — | — | EP | disclosed |