Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 16/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2330659 | 0.87 | GPR119 (0.73) | GPR119 | |
| SCHEMBL2450210 | 0.83 | GPR119 (0.78) | GPR119HRH3HRH1EPHX2 | |
| SCHEMBL11954339 | 0.83 | GPR119 (0.44) | GPR119HRH3HRH1 | |
| Hydrochloric Acid SCHEMBL2333331 | 0.82 | GPR119 (0.43) | GPR119HRH3HRH1 | |
| SCHEMBL3285206 | 0.81 | GPR119 (0.65) | GPR119HRH3HRH1EPHX2 | |
| SCHEMBL1550698 | 0.80 | GPR119 (0.55) | GPR119HRH3HRH1 | |
| SCHEMBL2454369 | 0.80 | GPR119 (0.78) | GPR119HRH3HRH1EPHX2 | |
| SCHEMBL2333549 | 0.79 | GPR119 (0.73) | GPR119 | |
| SCHEMBL2335413 | 0.77 | GPR119 (0.72) | GPR119HRH3HRH1EPHX2 | |
| SCHEMBL2452083 | 0.76 | GPR119 (0.61) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170864-A1 | PYRIDONE GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS | Bristol-Myers Squibb Company (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009012275-A1 | PYRIDONE GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-01-22 | — | — | WO | disclosed |