Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1B | O75688 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17893111 | 0.89 | PPM1B (0.38) | PPM1BPTPN1PPP1CCHSD11B1CNR2 | |
| SCHEMBL3652002 | 0.86 | MEN1 (0.40) | PPM1BPTPN1PPP1CCMAPT | |
| SCHEMBL2718339 | 0.82 | FKBP1A (0.34) | PPM1BPTPN1PPP1CCFKBP1A | |
| SCHEMBL15415792 | 0.78 | PPM1D (0.41) | PPM1BPTPN1PPP1CCHSD11B1FKBP1A | |
| SCHEMBL26117512 | 0.77 | MAPT (0.42) | MAPT | |
| SCHEMBL15712143 | 0.76 | PPM1B (0.53) | PPM1BPTPN1PPP1CCHSD11B1MAPT | |
| SCHEMBL8062803 | 0.76 | FKBP1A (0.33) | FKBP1A | |
| SCHEMBL12632024 | 0.76 | FKBP1A (0.33) | FKBP1A | |
| SCHEMBL19895093 | 0.75 | FKBP1A (0.31) | FKBP1A | |
| SCHEMBL22762028 | 0.74 | MAPT (0.36) | FKBP1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2407452-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme | Abbott Laboratories (US) | 2012-01-18 | — | — | EP | disclosed |