Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 13/20 | 0.72 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.70 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.70 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.70 |
| ▸ | PGR | P06401 | 2/20 | 0.70 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.70 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.70 |
| ▸ | HTR1A | P08908 | 1/20 | 0.70 |
| ▸ | CYP24A1 | Q07973 | 3/20 | 0.65 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.59 |
| ▸ | GC | P02774 | 1/20 | 0.59 |
| ▸ | RXRA | P19793 | 1/20 | 0.59 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.59 |
| ▸ | CNR1 | P21554 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12798585 | 0.86 | VDR (0.81) | VDRADORA3SLC6A2NR1I2PGR | |
| SCHEMBL12798567 | 0.86 | VDR (0.81) | VDRADORA3SLC6A2NR1I2PGR | |
| SCHEMBL13809910 | 0.85 | VDR (0.80) | VDRADORA3SLC6A2NR1I2PGR | |
| SCHEMBL19988245 | 0.85 | VDR (0.80) | VDRADORA3SLC6A2NR1I2PGR | |
| SCHEMBL10049538 | 0.85 | VDR (0.80) | VDRADORA3SLC6A2NR1I2PGR | |
| SCHEMBL13809909 | 0.85 | VDR (0.80) | VDRADORA3SLC6A2NR1I2PGR | |
| SCHEMBL10973273 | 0.85 | VDR (0.80) | VDRADORA3SLC6A2NR1I2PGR | |
| SCHEMBL13870052 | 0.85 | VDR (0.86) | VDRADORA3SLC6A2NR1I2PGR | |
| SCHEMBL14490722 | 0.85 | VDR (0.86) | VDRADORA3SLC6A2NR1I2PGR | |
| SCHEMBL14117370 | 0.85 | VDR (0.86) | VDRADORA3SLC6A2NR1I2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686435-A | Vitamin D amide derivatives | RESEARCH INSTITUTE FOR MEDICINE AND CHEMISTRY (US) | 1997-11-11 | — | — | US | claimed |
| EP-0614455-B1 | VITAMIN D AMIDE DERIVATIVES | RES INST MEDICINE CHEM (US) | 1996-02-21 | — | — | EP | claimed |
| US-7851461-B2 | acetylsalicylic acid, 1,25 dihydroxycholecalcipherol and calcium | COLOTECH A/S (DK) | 2010-12-14 | — | — | US | disclosed |
| US-20040116393-A1 | Prevention of epithelial cancer | COLOTECH A/S (DK) | 2004-06-17 | — | — | US | disclosed |
| US-5686435-A | Vitamin D amide derivatives | RESEARCH INSTITUTE FOR MEDICINE AND CHEMISTRY (US) | 1997-11-11 | — | — | US | disclosed |
| EP-0614455-B1 | VITAMIN D AMIDE DERIVATIVES | RES INST MEDICINE CHEM (US) | 1996-02-21 | — | — | EP | disclosed |
| WO-1993009093-A1 | VITAMIN D AMIDE DERIVATIVES | HOLMES, MICHAEL, JOHN (GB) | 1993-05-13 | — | — | WO | disclosed |