Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.47 |
| ▸ | LDHA | P00338 | 1/20 | 0.47 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.46 |
| ▸ | RPA1 | P27694 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13883208 | 0.86 | HCAR2 (0.47) | KMOMEN1KMT2AMAPTPOLB | |
| SCHEMBL1413913 | 0.83 | NPC1 (0.55) | KMOMEN1KMT2AMAPTPOLB | |
| SCHEMBL8366435 | 0.82 | NOTUM (0.57) | MEN1KMT2AMAPTPOLBNOTUM | |
| SCHEMBL31088355 | 0.82 | NOTUM (0.57) | MEN1KMT2AMAPTPOLBNOTUM | |
| SCHEMBL13883211 | 0.80 | HCAR2 (0.52) | KMOMEN1KMT2AMAPTPOLB | |
| SCHEMBL70360 | 0.80 | CA12 (0.53) | MEN1KMT2AMAPTPOLBHCAR2 | |
| SCHEMBL28168385 | 0.80 | NOTUM (0.53) | MEN1KMT2AMAPTNOTUMKDM4E | |
| SCHEMBL14152313 | 0.79 | HCAR2 (0.56) | KMOMEN1KMT2AMAPTPOLB | |
| SCHEMBL29019950 | 0.78 | MEN1 (0.51) | MEN1KMT2AMAPTPOLBHCAR2 | |
| SCHEMBL117667 | 0.78 | MARS1 (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167472-A2 | 1-BENZYLPYRAZOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-03-31 | — | — | EP | disclosed |
| WO-2009004171-A2 | 1-BENZYLPYRAZOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-01-08 | — | — | WO | disclosed |