Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | JAK1 | P23458 | 8/20 | 0.46 |
| ▸ | JAK3 | P52333 | 8/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.43 |
| ▸ | ATM | Q13315 | 3/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17766573 | 0.80 | JAK1 (0.47) | PDE4BJAK1JAK3KCNH2ATM | |
| SCHEMBL29229026 | 0.78 | CXCR2 (0.51) | PDE4BJAK1JAK3HSP90AA1HSP90AB1 | |
| SCHEMBL17766551 | 0.77 | JAK1 (0.53) | PDE4BJAK1JAK3KCNH2ATM | |
| SCHEMBL27700002 | 0.74 | JAK2 (0.36) | JAK1JAK3HSP90AA1HSP90AB1 | |
| SCHEMBL1220618 | 0.73 | KDM4E (0.51) | PDE4BJAK1JAK3HSP90AA1HSP90AB1 | |
| SCHEMBL12468339 | 0.72 | EML4 (0.46) | PDE4BJAK1JAK3CXCR2 | |
| SCHEMBL17766577 | 0.72 | MAP2K2 (0.42) | PDE4BJAK1JAK3HSP90AA1HSP90AB1 | |
| SCHEMBL12191238 | 0.71 | JAK2 (0.52) | JAK1JAK3HSP90AA1HSP90AB1KCNH2 | |
| SCHEMBL20111769 | 0.71 | HSP90AA1 (0.45) | PDE4BJAK1JAK3HSP90AA1HSP90AB1 | |
| SCHEMBL6153322 | 0.71 | FLT3 (0.47) | JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176231-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009013126-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-01-29 | — | — | WO | disclosed |