Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.70 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1906053 | 0.83 | GPR119 (0.63) | GPR119 | |
| SCHEMBL390342 | 0.82 | GPR119 (1.00) | GPR119HTTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL1834340 | 0.82 | GPR119 (0.65) | GPR119 | |
| SCHEMBL12733943 | 0.71 | GPR119 (0.81) | GPR119 | |
| SCHEMBL3975387 | 0.69 | GPR119 (0.52) | GPR119HTTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL5134301 | 0.69 | GPR119 (0.52) | GPR119HTTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL3120943 | 0.68 | GRM5 (0.55) | GPR119HTTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL24844566 | 0.67 | NPSR1 (0.48) | GPR119HTTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL31741445 | 0.67 | NPSR1 (0.48) | GPR119HTTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL13556311 | 0.66 | GPR119 (0.62) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2253311-A2 | Use of GPR119 receptor agonists for increasing bone mass and for treating osteoporosis, as well as combination therapy relating thereto | Arena Pharmaceuticals, Inc. (US) | 2010-11-24 | — | — | EP | disclosed |