Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | CNR2 | P34972 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3694391 | 1.00 | KMT2A (0.47) | KMT2AMEN1CNR2HDAC8HDAC1 | |
| SCHEMBL3694146 | 0.82 | HDAC8 (0.45) | KMT2AMEN1HDAC8HDAC1HDAC2 | |
| SCHEMBL3685268 | 0.82 | HDAC8 (0.45) | KMT2AMEN1HDAC8HDAC1HDAC2 | |
| SCHEMBL3683620 | 0.81 | PPARA (0.52) | KMT2AMEN1MAPTRAB9AKDM4E | |
| SCHEMBL3691832 | 0.81 | PPARA (0.52) | KMT2AMEN1MAPTRAB9AKDM4E | |
| SCHEMBL10275506 | 0.80 | MAPT (0.59) | KMT2AMEN1CNR2HDAC8HDAC1 | |
| SCHEMBL10275352 | 0.79 | MGAM (0.59) | KMT2AMEN1CNR2HDAC8HDAC1 | |
| SCHEMBL3683567 | 0.79 | PFKFB3 (0.60) | KMT2AMEN1CNR2HDAC8HDAC1 | |
| SCHEMBL10275051 | 0.79 | KMT2A (0.58) | KMT2AMEN1CNR2HDAC8HDAC1 | |
| SCHEMBL5101889 | 0.77 | CYP3A4 (0.55) | KMT2AMEN1CNR2HDAC8HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |