Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 4/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.51 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3685270 | 0.82 | PFKFB3 (0.58) | PFKFB3HDAC6KDM4EMAPTLMNA | |
| SCHEMBL3683621 | 0.82 | RAB9A (0.55) | KDM4EMAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL10309026 | 0.80 | PFKFB3 (0.72) | PFKFB3HDAC6KDM4EMAPTLMNA | |
| SCHEMBL10275508 | 0.80 | PFKFB3 (0.72) | PFKFB3HDAC6KDM4EMAPTLMNA | |
| SCHEMBL10275355 | 0.79 | PFKFB3 (0.81) | PFKFB3HDAC6KDM4EMAPTLMNA | |
| SCHEMBL10309039 | 0.79 | PFKFB3 (0.81) | PFKFB3HDAC6KDM4EMAPTLMNA | |
| SCHEMBL3683565 | 0.79 | KMT2A (0.47) | HDAC6KDM4EMAPTLMNASMN1; SMN2 | |
| SCHEMBL3694391 | 0.79 | KMT2A (0.47) | HDAC6KDM4EMAPTLMNASMN1; SMN2 | |
| SCHEMBL5507715 | 0.79 | PFKFB3 (0.74) | PFKFB3HDAC6KDM4EMAPTLMNA | |
| SCHEMBL10309012 | 0.79 | PFKFB3 (0.74) | PFKFB3HDAC6KDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | claimed |
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |