SCHEMBL3684481

SCHEMBL3684481

CN(C)Cc1cccc(C=CC(=O)c2cc(N3CCN(C)CC3)ccc2-c2ccccc2)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 8/20 0.48
HDAC4 P56524 8/20 0.48
HDAC1 Q13547 8/20 0.48
HDAC7 Q8WUI4 8/20 0.48
HDAC2 Q92769 8/20 0.48
HDAC10 Q969S8 8/20 0.48
HDAC11 Q96DB2 8/20 0.48
HDAC8 Q9BY41 8/20 0.48
HDAC6 Q9UBN7 8/20 0.48
HDAC9 Q9UKV0 8/20 0.48
HDAC5 Q9UQL6 8/20 0.48
PIM2 Q9P1W9 3/20 0.46
PIM1 P11309 2/20 0.46
AOC3 Q16853 2/20 0.44
CSNK2A2 P19784 1/20 0.44
CSNK2A1 P68400 1/20 0.44
ABCB1 P08183 2/20 0.42
HTR6 P50406 2/20 0.42
ESR1 P03372 1/20 0.41
HTR1A P08908 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3688945 1.00 HDAC3 (0.48) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3686623 0.85 ABCB1 (0.45) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3688874 0.85 ABCB1 (0.45) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3688796 0.85 HDAC4 (0.57) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3696555 0.84 HDAC4 (0.47) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3686026 0.82 HDAC4 (0.67) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3684483 0.81 HDAC3 (0.49) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3687425 0.81 HDAC3 (0.53) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3685239 0.81 HDAC3 (0.53) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3692294 0.78 HDAC4 (0.49) HDAC3HDAC4HDAC1HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060235073-A1 Diamino-functional chalcones LICA PHARMACEUTICALS A/S (DK) 2006-10-19 US claimed
US-7642367-B2 Diamino-functional chalcones LICA PHARMACEUTICALS A/S (DK) 2010-01-05 US disclosed
US-20060235073-A1 Diamino-functional chalcones LICA PHARMACEUTICALS A/S (DK) 2006-10-19 US disclosed