Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL463372 | 1.00 | TSHR (0.31) | TSHRALDH1A1ACHE | |
| Bromide SCHEMBL368454 | 0.96 | — | — | |
| Hydrogen Sulfide SCHEMBL28090943 | 0.96 | TSHR (0.33) | TSHRALDH1A1 | |
| SCHEMBL197824 | 0.96 | TSHR (0.33) | TSHRALDH1A1 | |
| Bromide SCHEMBL28874797 | 0.93 | — | — | |
| SCHEMBL596385 | 0.92 | TSHR (0.31) | TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL20896 | 0.92 | TSHR (0.31) | TSHRALDH1A1 | |
| Iodide SCHEMBL2796494 | 0.92 | TSHR (0.31) | TSHRALDH1A1 | |
| Fluoride Ion SCHEMBL1260645 | 0.92 | TSHR (0.31) | TSHRALDH1A1 | |
| Fluoride Ion SCHEMBL33106 | 0.92 | TSHR (0.31) | TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 202 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174687-A1 | PROCESS FOR THE PREPARATION OF BROMINATED COPOLYMERS OF CONJUGATED DIENES AND STYRENIC MONOMERS | LANXESS CORPORATION (US) | 2023-06-08 | — | — | US | claimed |
| CN-104177516-A | Bromized aliphatic olefin/vinyl aromatic copolymer flame retardant and preparation method thereof | QINGDAO FUNDCHEM CO LTD | 2014-12-03 | — | — | CN | claimed |
| US-8779066-B2 | Process for brominating butadiene polymers using ester solvent mixtures | DOW GLOBAL TECHNOLOGIES LLC (US) | 2014-07-15 | — | — | US | claimed |
| US-20140121330-A1 | PROCESS FOR BROMINATING BUTADIENE POLYMERS USING ESTER SOLVENT MIXTURES | THE DOW CHEMICAL COMPANY | 2014-05-01 | — | — | US | claimed |
| CN-102257016-B | Process for brominating butadiene polymers using ester solvent mixtures | DOW GLOBAL TECHNOLOGIES INC | 2014-04-09 | — | — | CN | claimed |
| EP-2379605-B1 | PROCESS FOR BROMINATING BUTADIENE POLYMERS USING ESTER SOLVENT MIXTURES | DOW GLOBAL TECHNOLOGIES LLC (US) | 2014-03-12 | — | — | EP | claimed |
| CN-101959901-B | Process for brominating butadiene copolymers by the addition of water or certain solvents | DOW GLOBAL TECHNOLOGIES LLC | 2013-05-08 | — | — | CN | claimed |
| US-8410226-B2 | Two-step process for brominating butadiene copolymers | DOW GLOBAL TECHNOLOGIES LLC (US) | 2013-04-02 | — | — | US | claimed |
| CN-102015774-B | Two-step process for brominating butadiene copolymers | DOW GLOBAL TECHNOLOGIES INC | 2013-01-02 | — | — | CN | claimed |
| EP-2274338-B1 | TWO-STEP PROCESS FOR BROMINATING BUTADIENE COPOLYMERS | DOW GLOBAL TECHNOLOGIES LLC (US) | 2012-12-12 | — | — | EP | claimed |
| WO-2009139942-A2 | PROCESS FOR BROMINATING BUTADIENE COPOLYMERS BY THE ADDITION OF WATER OR CERTAIN SOLVENTS | DOW GLOBAL TECHNOLOGIES INC. (US) | 2009-11-19 | — | — | WO | claimed |
| CN-101583631-A | Process for brominating butadiene/vinyl aromatic copolymers | DOW GLOBAL TECHNOLOGIES INC (US) | 2009-11-18 | — | — | CN | claimed |
| WO-2009134628-A1 | TWO-STEP PROCESS FOR BROMINATING BUTADIENE COPOLYMERS | DOW GLOBAL TECHNOLOGIES INC. (US) | 2009-11-05 | — | — | WO | claimed |
| US-7605267-B2 | Process for the preparation of 5-(halocetyl)-8-(substituted oxy)-(1h)-quinolin-2-ones | NOVARTIS AG (CH) | 2009-10-20 | — | — | US | claimed |
| EP-2054445-A2 | PROCESS FOR BROMINATING BUTADIENE/VINYL AROMATIC COPOLYMERS | Dow Global Technologies Inc. (US) | 2009-05-06 | — | — | EP | claimed |
| WO-2008021417-A2 | PROCESS FOR BROMINATING BUTADIENE/VINYL AROMATIC COPOLYMERS | DOW GLOBAL TECHNOLOGIES, INC. (US) | 2008-02-21 | — | — | WO | claimed |
| JP-2006522055-A | — | — | 2006-09-28 | — | — | JP | claimed |
| US-20060189653-A1 | Process for the preparation of 5-(halocetyl)-8-(substituted oxy)-(1h)-quinolin-2-ones | NOVARTIS AG (CH) | 2006-08-24 | — | — | US | claimed |
| EP-1613599-A1 | A PROCESS FOR THE PREPARATION OF 5-(HALOACETYL)-8-(SUBSTITUTED OXY)-(1H)-QUINOLIN-2-ONES | Novartis AG (CH) | 2006-01-11 | — | — | EP | claimed |
| WO-2004087668-A1 | A PROCESS FOR THE PREPARATION OF 5-(HALOACETYL)-8-(SUBSTITUTED OXY)-(1H)-QUINOLIN-2-ONES | NOVARTIS AG (CH) | 2004-10-14 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189653-A1 | Process for the preparation of 5-(halocetyl)-8-(substituted oxy)-(1h)-quinolin-2-ones | UGT8, KAT8, UGT1A8 | ACHE 1054/4885TSHR 1260/4885ALDH1A1 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.