Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 11/20 | 0.59 |
| ▸ | MAOA | P21397 | 3/20 | 0.59 |
| ▸ | CXCL12 | P48061 | 2/20 | 0.57 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.55 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3688379 | 1.00 | MAOB (0.59) | MAOBMAOACXCL12CYP1B1CRHBP | |
| SCHEMBL3684551 | 1.00 | MAOB (0.59) | MAOBMAOACXCL12CYP1B1CRHBP | |
| SCHEMBL25197170 | 0.90 | MAOB (0.59) | MAOBMAOACXCL12CYP1B1CRHBP | |
| SCHEMBL25194492 | 0.90 | MAOB (0.59) | MAOBMAOACXCL12CYP1B1CRHBP | |
| SCHEMBL3684185 | 0.87 | TNFRSF1A (0.63) | MAOBMAOACYP1B1CRHBPCRHR2 | |
| SCHEMBL3684182 | 0.87 | TNFRSF1A (0.63) | MAOBMAOACYP1B1CRHBPCRHR2 | |
| SCHEMBL3693367 | 0.87 | TNFRSF1A (0.63) | MAOBMAOACYP1B1CRHBPCRHR2 | |
| SCHEMBL3694987 | 0.86 | MAPT (0.68) | MAOBCYP1B1CRHBPCRHR2TLR9 | |
| SCHEMBL3686088 | 0.86 | MAPT (0.68) | MAOBCYP1B1CRHBPCRHR2TLR9 | |
| SCHEMBL3686086 | 0.86 | MAPT (0.68) | MAOBCYP1B1CRHBPCRHR2TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |