Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | USP2 | O75604 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | RECQL | P46063 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | CRHBP | P24387 | 1/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3694987 | 1.00 | MAPT (0.68) | MAPTMAPK1TLR9KMT2AMEN1 | |
| SCHEMBL3686088 | 1.00 | MAPT (0.68) | MAPTMAPK1TLR9KMT2AMEN1 | |
| SCHEMBL2909651 | 0.88 | MAPT (0.86) | MAPTMAPK1TLR9KMT2AMEN1 | |
| SCHEMBL2909650 | 0.88 | MAPT (0.86) | MAPTMAPK1TLR9KMT2AMEN1 | |
| SCHEMBL3684185 | 0.86 | TNFRSF1A (0.63) | MAPTMAPK1TLR9KMT2AMEN1 | |
| SCHEMBL3693367 | 0.86 | TNFRSF1A (0.63) | MAPTMAPK1TLR9KMT2AMEN1 | |
| SCHEMBL3684551 | 0.86 | MAOB (0.59) | MAPTTLR9KMT2ACRHBPCRHR2 | |
| SCHEMBL3684182 | 0.86 | TNFRSF1A (0.63) | MAPTMAPK1TLR9KMT2AMEN1 | |
| SCHEMBL3688379 | 0.86 | MAOB (0.59) | MAPTTLR9KMT2ACRHBPCRHR2 | |
| SCHEMBL3684549 | 0.86 | MAOB (0.59) | MAPTTLR9KMT2ACRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |