Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3693924 | 0.84 | ALDH1A1 (0.47) | ALDH1A1TUBB1CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL580616 | 0.80 | ALDH1A1 (0.48) | ALDH1A1TUBB1CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL16428890 | 0.80 | ALDH1A1 (0.48) | ALDH1A1TUBB1CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL30679140 | 0.80 | ALDH1A1 (0.48) | ALDH1A1TUBB1CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL3696806 | 0.77 | ALDH1A1 (0.46) | ALDH1A1TUBB1CYP1A2CYP2C19HPGD | |
| SCHEMBL31063449 | 0.77 | ALDH1A1 (0.46) | ALDH1A1TUBB1CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL20789993 | 0.77 | ALDH1A1 (0.50) | ALDH1A1TUBB1CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL20789980 | 0.77 | ALDH1A1 (0.46) | ALDH1A1TUBB1CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL7812572 | 0.77 | ALDH1A1 (0.46) | ALDH1A1TUBB1CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL136020 | 0.76 | ALDH1A1 (0.42) | ALDH1A1TUBB1CYP1A2CYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |
| US-20060052600-A1 | Amino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-03-09 | — | — | US | disclosed |
| EP-1506157-A2 | AMINO-FUNCTIONAL CHALCONES | Lica Pharmaceuticals A/S (DK) | 2005-02-16 | — | — | EP | disclosed |
| EP-1506158-A2 | DIAMINO-FUNCTIONAL CHALCONES | Lica Pharmaceuticals A/S (DK) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097576-A2 | DIAMINO-FUNCTIONAL CHALCONES | LICA PHARMACEUTICALS A/S (DK) | 2003-11-27 | — | — | WO | disclosed |
| WO-2003097575-A2 | AMINO-FUNCTIONAL CHALCONES | LICA PHARMACEUTICALS A/S (DK) | 2003-11-27 | — | — | WO | disclosed |