Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 12/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3689503 | 0.84 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CBPIK3R1EPHB3 | |
| SCHEMBL3687917 | 0.84 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL3687915 | 0.84 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL17453430 | 0.80 | EIF4A3 (0.43) | NPC1RAB9AKDM4ETP53ALDH1A1 | |
| SCHEMBL13139955 | 0.80 | EPHB3 (0.56) | NPC1RAB9AKDM4ETP53ALDH1A1 | |
| SCHEMBL3606337 | 0.80 | NPC1 (0.45) | NPC1RAB9AKDM4ETP53ALDH1A1 | |
| SCHEMBL3077986 | 0.78 | NPC1 (0.44) | NPC1RAB9AKDM4ETP53ALDH1A1 | |
| SCHEMBL3077903 | 0.78 | NPC1 (0.47) | PIK3CDPIK3CAPIK3CBNPC1RAB9A | |
| SCHEMBL26765489 | 0.78 | EPHB3 (0.58) | NPC1RAB9AKDM4ETP53ALDH1A1 | |
| SCHEMBL17324605 | 0.76 | EPHB3 (0.59) | NPC1RAB9AKDM4ETP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010074586-A1 | PYRAZOLO[1,5-A]PYRIDINE AND IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AND THEIR USE IN CANCER THERAPY | PATHWAY THERAPEUTICS LIMITED (NZ) | 2010-07-01 | — | — | WO | disclosed |
| EP-2188292-A1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D]PYRIMIDIN-4-YL) AMINO]BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009020990-A1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D] PYRIMIDIN-4-YL) AMINO] BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |