SCHEMBL3686071

SCHEMBL3686071

CNC(=N)C1=NN(c2ccc(Cl)cc2Cl)C(c2ccccc2)C1

nearest known ligand 0.59

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 15/20 0.59
CNR2 P34972 8/20 0.59
KIF11 P52732 1/20 0.43
ESD P10768 1/20 0.41
DRD2 P14416 3/20 0.38
DRD4 P21917 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3680872 0.85 CNR1 (0.56) CNR1CNR2
Hydrochloric Acid SCHEMBL3557985 0.84 CNR1 (0.56) CNR1CNR2KIF11ESDDRD2
SCHEMBL3569818 0.80 CNR1 (0.68) CNR1CNR2
SCHEMBL3562281 0.78 CNR1 (0.72) CNR1CNR2
SCHEMBL13313062 0.78 CNR1 (0.72) CNR1CNR2
SCHEMBL31429978 0.78 ALDH1A1 (0.57) CNR1CNR2KIF11
SCHEMBL4605360 0.76 CNR1 (0.59) CNR1CNR2
SCHEMBL1748630 0.76 CNR1 (0.65) CNR1CNR2KIF11
SCHEMBL1748655 0.76 CNR1 (0.65) CNR1CNR2KIF11
SCHEMBL31589469 0.76 CNR1 (0.65) CNR1CNR2KIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7763607-B2 Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators SOLVAY PHARMACEUTICALS GMBH (DE) 2010-07-27 US claimed
EP-2012775-A1 USE OF CBX CANNABINOID RECEPTOR MODULATORS AS POTASSIUM CHANNEL MODULATORS Solvay Pharmaceuticals GmbH (DE) 2009-01-14 EP claimed
WO-2007125049-A1 USE OF CBX CANNABINOID RECEPTOR MODULATORS AS POTASSIUM CHANNEL MODULATORS SOLVAY PHARMACEUTICALS GMBH (DE) 2007-11-08 WO claimed
US-20070254863-A1 Use of CBx cannabinoid receptor modulators as potassium channel modulators SOLVAY PHARMACEUTICALS GMBH (DE) 2007-11-01 US claimed
US-20070254862-A1 Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators SOLVAY PHARMACEUTICALS GMBH (DE) 2007-11-01 US claimed
US-7763607-B2 Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators SOLVAY PHARMACEUTICALS GMBH (DE) 2010-07-27 US disclosed
EP-2026798-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING CBX CANNABINOID RECEPTOR MODULATORS AND POTASSIUM CHANNEL MODULATORS Solvay Pharmaceuticals GmbH (DE) 2009-02-25 EP disclosed
EP-2012775-A1 USE OF CBX CANNABINOID RECEPTOR MODULATORS AS POTASSIUM CHANNEL MODULATORS Solvay Pharmaceuticals GmbH (DE) 2009-01-14 EP disclosed
WO-2007125048-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING CBX CANNABINOID RECEPTOR MODULATORS AND POTASSIUM CHANNEL MODULATORS SOLVAY PHARMACEUTICALS GMBH (DE) 2007-11-08 WO disclosed
WO-2007125049-A1 USE OF CBX CANNABINOID RECEPTOR MODULATORS AS POTASSIUM CHANNEL MODULATORS SOLVAY PHARMACEUTICALS GMBH (DE) 2007-11-08 WO disclosed
US-20070254863-A1 Use of CBx cannabinoid receptor modulators as potassium channel modulators SOLVAY PHARMACEUTICALS GMBH (DE) 2007-11-01 US disclosed
US-20070254862-A1 Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators SOLVAY PHARMACEUTICALS GMBH (DE) 2007-11-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070254863-A1 Use of CBx cannabinoid receptor modulators as potassium channel modulators CNR2, CNR1, KCNN1 CNR1 2/4885CNR2 1/4885KIF11 2062/4885
US-20070254862-A1 Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators CNR1, CNR2, KCNJ11 CNR1 1/4885CNR2 2/4885KIF11 1518/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.