Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 5/20 | 0.45 |
| ▸ | MAOB | P27338 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3692967 | 1.00 | MAOA (0.45) | MAOAMAOBMAPTMEN1MAPK1 | |
| SCHEMBL3687549 | 0.86 | MAOA (0.49) | MAOAMAOBMAPTMEN1MAPK1 | |
| SCHEMBL3688202 | 0.86 | MAOA (0.49) | MAOAMAOBMAPTMEN1MAPK1 | |
| SCHEMBL3687692 | 0.82 | HDAC3 (0.68) | MAOAMAOBHDAC6HDAC3HDAC4 | |
| SCHEMBL3693286 | 0.82 | HDAC3 (0.68) | MAOAMAOBHDAC6HDAC3HDAC4 | |
| SCHEMBL3684640 | 0.82 | MAPT (0.59) | MAOBMAPTMEN1MAPK1KMT2A | |
| SCHEMBL3682132 | 0.82 | MAPT (0.59) | MAOBMAPTMEN1MAPK1KMT2A | |
| SCHEMBL5915675 | 0.81 | HDAC6 (0.57) | MAOAMAOBMAPTMEN1MAPK1 | |
| SCHEMBL3691944 | 0.81 | MAPT (0.51) | MAOAMAOBMAPTMEN1MAPK1 | |
| SCHEMBL3688010 | 0.81 | MAPT (0.51) | MAOAMAOBMAPTMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |