Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 2/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3648036 | 0.84 | RAB9A (0.42) | KDM4EMEN1ALDH1A1KMT2ANPC1 | |
| SCHEMBL3351202 | 0.81 | NPC1 (0.48) | KDM4EMEN1ALDH1A1KMT2ANPC1 | |
| SCHEMBL3506848 | 0.81 | RAB9A (0.40) | KDM4EMEN1ALDH1A1KMT2ANPC1 | |
| SCHEMBL3511239 | 0.80 | SLC5A7 (0.46) | KDM4EALDH1A1NPC1RAB9AUSP2 | |
| SCHEMBL3509460 | 0.79 | SLC5A7 (0.45) | KDM4EALDH1A1NPC1RAB9ANR1H4 | |
| SCHEMBL3641877 | 0.79 | NPC1 (0.41) | KDM4EMEN1ALDH1A1KMT2ANPC1 | |
| SCHEMBL3509205 | 0.76 | RAB9A (0.41) | KDM4EMEN1ALDH1A1KMT2ANPC1 | |
| SCHEMBL3648778 | 0.75 | MKNK1 (0.42) | NPC1RAB9ALOXL2ALOX15 | |
| SCHEMBL166274 | 0.74 | NPC1 (0.43) | KDM4EMEN1ALDH1A1KMT2ANPC1 | |
| SCHEMBL3511235 | 0.73 | IKBKB (0.36) | KDM4EMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178837-A2 | ISOPHTHALAMIDE DERIVATIVES INHIBITING BETA-SECRETASE ACTIVITY | COMENTIS, INC. (US) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009015369-A2 | COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |