Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 6/20 | 1.00 |
| ▸ | GAA | P10253 | 6/20 | 1.00 |
| ▸ | SI | P14410 | 6/20 | 1.00 |
| ▸ | MGAM2 | Q2M2H8 | 6/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.56 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27965552 | 0.83 | MGAM (0.72) | MGAMGAASIMGAM2PKM | |
| SCHEMBL367666 | 0.81 | GAA (1.00) | MGAMGAASIMGAM2PKM | |
| SCHEMBL10752099 | 0.79 | MGAM (0.66) | MGAMGAASIMGAM2PKM | |
| SCHEMBL13723187 | 0.79 | GAA (0.66) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL968285 | 0.79 | MGAM (0.66) | MGAMGAASIMGAM2PKM | |
| SCHEMBL28850576 | 0.79 | MGAM (0.65) | MGAMGAASIMGAM2PKM | |
| SCHEMBL27915214 | 0.78 | GAA (0.63) | MGAMGAASIMGAM2PKM | |
| SCHEMBL15130146 | 0.78 | MGAM (0.65) | MGAMGAASIMGAM2PKM | |
| SCHEMBL15130069 | 0.76 | MGAM (0.63) | MGAMGAASIMGAM2PKM | |
| SCHEMBL5172858 | 0.76 | GAA (0.60) | MGAMGAASIMGAM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119371374-A | Green synthesis method of 2-amino-5-aryl-1, 3, 4-thiadiazole | 陕西科技大学 | 2025-01-28 | — | — | CN | disclosed |
| CN-118255729-A | Method for synthesizing 2-amino-5-substituted-1, 3, 4-thiadiazole | 陕西科技大学 | 2024-06-28 | — | — | CN | disclosed |
| CN-118221668-A | Indometacin derivative containing 2-amino-1, 3, 4-thiadiazole and preparation method and application thereof | 华南农业大学 | 2024-06-21 | — | — | CN | disclosed |
| WO-2023101326-A1 | NOVEL COMPOUND AS AUTOTAXIN INHIBITOR AND USE THEREOF | 주식회사 넥스트젠바이오사이언스 | 2023-06-08 | — | — | WO | disclosed |
| CN-110878106-B | Preparation method of Mannich base containing ferrocenyl thiadiazole or oxadiazolyl | 陕西科技大学 | 2022-05-03 | — | — | CN | disclosed |
| CN-110627783-B | Preparation method of Schiff base containing carbazolyl and oxadiazolyl or thiadiazolyl | 陕西科技大学 | 2021-11-16 | — | — | CN | disclosed |
| CN-112920181-A | N- (5-phenyl-1, 3, 4-thiadiazole-2-yl) benzamide compound | 中国医科大学 | 2021-06-08 | — | — | CN | disclosed |
| CN-110878106-A | Preparation method of Mannich base containing ferrocenyl thiadiazole or oxadiazolyl | 陕西科技大学 | 2020-03-13 | — | — | CN | disclosed |
| CN-110759955-A | Preparation method of Mannich base containing ferrocenyl thiadiazole or oxadiazolyl | 陕西科技大学 | 2020-02-07 | — | — | CN | disclosed |
| CN-110627783-A | Preparation method of Schiff base containing carbazolyl and oxadiazolyl or thiadiazolyl | 陕西科技大学 | 2019-12-31 | — | — | CN | disclosed |
| US-9066948-B2 | Oxadiazolo[3,2-a]pyrimidines and thiadiazolo[3,2-a]pyrimidines | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2015-06-30 | — | — | US | disclosed |
| WO-2014147021-A2 | NOVEL COMPOUNDS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-09-25 | — | — | WO | disclosed |
| CN-103936691-A | Method for preparing 2-amino-5-substituted-1,3,4-thiadiazole | UNIV SHAANXI SCIENCE & TECH | 2014-07-23 | — | — | CN | disclosed |
| CN-103936692-A | Method for preparing 2-amino-5-aryl-1,3,4-thiadiazole | UNIV SHAANXI SCIENCE & TECH | 2014-07-23 | — | — | CN | disclosed |
| CN-103864776-A | Tegafur derivative containing 1,3,4-thiadiazole heterocyclic ring and amide group | INST OF MATERIA MEDICA SHANDONG ACADEMY OF MEDICAL SCIENCES | 2014-06-18 | — | — | CN | disclosed |
| US-20130251761-A1 | ORGANIC COMPOUNDS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-09-26 | — | — | US | disclosed |
| EP-2593106-A1 | ORGANIC COMPOUNDS | Rockefeller University (US) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012009688-A1 | ORGANIC COMPOUNDS | ROCKEFELLER UNIVERSITY (US) | 2012-01-19 | — | — | WO | disclosed |
| US-4233214-A | FOR POLYACRYLONITRILE AND ACID-MODIFIED POLYESTERS OR POLYAMIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1980-11-11 | — | — | US | disclosed |
| US-4036826-A | Cationic azo dyestuffs with a hydroxyalkylated ammonium group | BAYER AKTIENGESELLSCHAFT (DT) | 1977-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130251761-A1 | ORGANIC COMPOUNDS | PLAT, ICAM1, VCAM1 | MGAM 3501/4885GAA 1692/4885SI 4217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.