Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 7/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.53 |
| ▸ | TUBB | P07437 | 5/20 | 0.53 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.53 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.53 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.53 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.53 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.53 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.53 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.53 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.53 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.53 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.53 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.53 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.53 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3683355 | 1.00 | TUBB1 (0.53) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3688491 | 0.93 | TUBB4A (0.53) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3688837 | 0.93 | TUBB4A (0.53) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3696659 | 0.89 | KRAS (0.45) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3686108 | 0.89 | KRAS (0.45) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3689870 | 0.89 | HDAC3 (0.51) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3688445 | 0.89 | HDAC3 (0.51) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3690334 | 0.87 | HDAC3 (0.45) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3688315 | 0.87 | HDAC3 (0.45) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3690821 | 0.87 | TUBB4A (0.45) | TUBB1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | claimed |
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |