Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 2/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29853295 | 0.78 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2AMAPTRAB9A | |
| SCHEMBL3358934 | 0.74 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2AMAPTRAB9A | |
| SCHEMBL11756021 | 0.74 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2AMAPTRAB9A | |
| SCHEMBL11756014 | 0.74 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2AMAPTRAB9A | |
| SCHEMBL10818068 | 0.74 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2AMAPTRAB9A | |
| Azobenzene SCHEMBL11878769 | 0.73 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2AMAPTRAB9A | |
| Azobenzene SCHEMBL32032 | 0.73 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2AMAPTRAB9A | |
| Azobenzene SCHEMBL6562161 | 0.73 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2AMAPTRAB9A | |
| Azobenzene SCHEMBL11124477 | 0.73 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2AMAPTRAB9A | |
| Azobenzene SCHEMBL6703357 | 0.73 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2AMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170839-B1 | ALKYNYLPYRIMIDINES AS TIE2 KINASE INHIBITORS | BAYER IP GMBH (DE) | 2015-09-09 | — | — | EP | disclosed |
| EP-2170839-A1 | ALKYNYLPYRIMIDINES AS TIE2 KINASE INHIBITORS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2010-04-07 | — | — | EP | disclosed |
| EP-2022785-A1 | Alkynylpyrimidines as Tie2 kinase inhibitors | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-02-11 | — | — | EP | disclosed |
| WO-2008155140-A1 | ALKYNYLPYRIMIDINES AS TIE2 KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-12-24 | — | — | WO | disclosed |