Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | TNKS | O95271 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | GUSB | P08236 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | GSK3A | P49840 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | RGS12 | O14924 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12762527 | 0.83 | KDM4E (0.48) | KDM4ETNKSPARP1TNKS2MAPT | |
| SCHEMBL1514119 | 0.82 | KDM4E (0.47) | KDM4ETNKSPARP1TNKS2HSD11B1 | |
| SCHEMBL1513942 | 0.82 | KDM4E (0.47) | KDM4ETNKSPARP1TNKS2MAPT | |
| SCHEMBL1514029 | 0.81 | KDM4E (0.46) | KDM4EGSK3B | |
| SCHEMBL1514005 | 0.81 | KDM4E (0.46) | KDM4ETNKSPARP1TNKS2MAPT | |
| SCHEMBL1513997 | 0.80 | KDM4E (0.46) | KDM4ENPC1MAPTGSK3BPOLB | |
| SCHEMBL3686748 | 0.79 | KDM4E (0.44) | KDM4ETNKSPARP1TNKS2MAPT | |
| SCHEMBL12552085 | 0.79 | KDM4E (0.54) | KDM4ETNKSHSD11B1MAPTALDH1A1 | |
| SCHEMBL3676712 | 0.79 | KDM4E (0.44) | KDM4ETNKSPARP1TNKS2NPC1 | |
| SCHEMBL1514004 | 0.77 | KDM4E (0.43) | KDM4ETNKSPARP1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176264-A1 | IMIDAZO-, PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES AND THEIR USE | Bayer Schering Pharma AG (DE) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009007029-A1 | IMIDAZO-, PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES AND THEIR USE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-01-15 | — | — | WO | disclosed |