Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3686748 | 0.86 | KDM4E (0.44) | KDM4ETNKSPARP1TNKS2MAPT | |
| SCHEMBL1513997 | 0.84 | KDM4E (0.46) | KDM4EADORA3TSHRMAPTNPC1 | |
| SCHEMBL3674841 | 0.80 | MAPT (0.44) | KDM4ETSHRMAPTCNR1NPC1 | |
| SCHEMBL12762527 | 0.79 | KDM4E (0.48) | KDM4ETNKSPARP1TNKS2MAPT | |
| SCHEMBL3687396 | 0.79 | KDM4E (0.55) | KDM4ETNKSPARP1TNKS2MAPT | |
| SCHEMBL1513942 | 0.77 | KDM4E (0.47) | KDM4ETNKSPARP1TNKS2MAPT | |
| SCHEMBL12835585 | 0.76 | ADORA3 (0.44) | KDM4EADORA3TNKSPARP1TNKS2 | |
| SCHEMBL1514005 | 0.75 | KDM4E (0.46) | KDM4ETNKSPARP1TNKS2MAPT | |
| SCHEMBL1514119 | 0.72 | KDM4E (0.47) | KDM4ETNKSPARP1TNKS2MAPT | |
| SCHEMBL1110696 | 0.69 | ALDH1A1 (0.46) | KDM4ETSHRMAPTMAPK1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176264-B1 | IMIDAZO-, PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES FOR TREATING HEMATOLOGICAL DISORDERS | BAYER IP GMBH (DE) | 2012-12-19 | — | — | EP | disclosed |
| EP-2176264-A1 | IMIDAZO-, PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES AND THEIR USE | Bayer Schering Pharma AG (DE) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009007029-A1 | IMIDAZO-, PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES AND THEIR USE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-01-15 | — | — | WO | disclosed |