Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 7/20 | 0.43 |
| ▸ | JAK2 | O60674 | 5/20 | 0.43 |
| ▸ | JAK3 | P52333 | 5/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 4/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370914 | 0.89 | NPBWR1 (0.48) | NPBWR1L3MBTL1ALOX15MCHR1UCHL1 | |
| SCHEMBL369444 | 0.86 | NPBWR1 (0.48) | NPBWR1L3MBTL1ALOX15MCHR1POLB | |
| SCHEMBL369974 | 0.86 | NPBWR1 (0.48) | NPBWR1L3MBTL1ALOX15MCHR1UCHL1 | |
| SCHEMBL371091 | 0.83 | NPBWR1 (0.45) | NPBWR1L3MBTL1ALOX15MCHR1UCHL1 | |
| SCHEMBL370615 | 0.81 | NPBWR1 (0.44) | NPBWR1L3MBTL1ALOX15MCHR1UCHL1 | |
| SCHEMBL7982141 | 0.80 | NPBWR1 (0.48) | NPBWR1L3MBTL1ALOX15PDE2ABRD4 | |
| SCHEMBL30739057 | 0.78 | NPC1 (0.42) | NPBWR1L3MBTL1POLB | |
| SCHEMBL30739173 | 0.76 | NPC1 (0.42) | NPBWR1L3MBTL1 | |
| SCHEMBL15130310 | 0.76 | NPBWR1 (0.39) | NPBWR1L3MBTL1ALOX15JAK1JAK2 | |
| SCHEMBL3357317 | 0.75 | NPBWR1 (0.49) | NPBWR1L3MBTL1ALOX15PDE2AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595986-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012009009-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2012-01-19 | — | — | WO | disclosed |