Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 11/20 | 0.53 |
| ▸ | KDR | P35968 | 10/20 | 0.53 |
| ▸ | MST1R | Q04912 | 3/20 | 0.53 |
| ▸ | HGF | P14210 | 2/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.53 |
| ▸ | TEK | Q02763 | 2/20 | 0.53 |
| ▸ | BTK | Q06187 | 2/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 4/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL368467 | 0.98 | KDR (0.55) | METKDRMST1RHGFRPS6KB1 | |
| SCHEMBL368940 | 0.98 | KDR (0.55) | METKDRMST1RHGFRPS6KB1 | |
| SCHEMBL368364 | 0.96 | KDR (0.52) | METKDRMST1RHGFRPS6KB1 | |
| SCHEMBL369342 | 0.93 | KDR (0.52) | METKDRMST1RHGFRPS6KB1 | |
| SCHEMBL368396 | 0.91 | KDR (0.53) | METKDRMST1RHGFRPS6KB1 | |
| SCHEMBL368772 | 0.89 | KDR (0.44) | METKDRMST1RHGFRPS6KB1 | |
| SCHEMBL361179 | 0.86 | MET (0.69) | METKDRMST1RHGFRPS6KB1 | |
| SCHEMBL369483 | 0.86 | KDR (0.49) | METKDRMST1RHGFRPS6KB1 | |
| SCHEMBL363057 | 0.81 | MET (0.66) | METKDRMST1RHGFRPS6KB1 | |
| SCHEMBL14937303 | 0.80 | RAF1 (0.38) | METKDRMST1RHGFRPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593462-A1 | NOVEL FUSED HETEROCYCLIC DERIVATIVES USEFUL AS c-MET TYROSINE KINASE INHIBITORS | Zhejiang Beta Pharma Inc. (CN) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012006960-A1 | NOVEL FUSED HETEROCYCLIC DERIVATIVES USEFUL AS c-MET TYROSINE KINASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | disclosed |