Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F3 | P13726 | 2/20 | 0.64 |
| ▸ | MAOB | P27338 | 8/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 3/20 | 0.59 |
| ▸ | XDH | P47989 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | P4HB | P07237 | 1/20 | 0.59 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | BCHE | P06276 | 3/20 | 0.58 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.57 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.57 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.56 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.56 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3688596 | 1.00 | F3 (0.64) | F3MAOBMAPTNPC1LMNA | |
| SCHEMBL3693312 | 1.00 | F3 (0.64) | F3MAOBMAPTNPC1LMNA | |
| SCHEMBL3693412 | 1.00 | F3 (0.64) | F3MAOBMAPTNPC1LMNA | |
| SCHEMBL3683962 | 0.89 | CYP1B1 (0.55) | F3MAOBMAPTNPC1LMNA | |
| SCHEMBL3693304 | 0.89 | ABCG2 (0.65) | F3MAOBMAPTNPC1LMNA | |
| SCHEMBL3683960 | 0.89 | ABCG2 (0.65) | F3MAOBMAPTNPC1LMNA | |
| SCHEMBL3692091 | 0.87 | BCHE (0.60) | MAOBMAPTNPC1LMNAMAOA | |
| SCHEMBL3692089 | 0.87 | BCHE (0.60) | MAOBMAPTNPC1LMNAMAOA | |
| SCHEMBL3695023 | 0.87 | BCHE (0.60) | MAOBMAPTNPC1LMNAMAOA | |
| SCHEMBL3685113 | 0.86 | BCHE (0.58) | F3MAOBMAPTNPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | claimed |
| EP-1506158-A2 | DIAMINO-FUNCTIONAL CHALCONES | Lica Pharmaceuticals A/S (DK) | 2005-02-16 | — | — | EP | claimed |
| WO-2003097576-A2 | DIAMINO-FUNCTIONAL CHALCONES | LICA PHARMACEUTICALS A/S (DK) | 2003-11-27 | — | — | WO | claimed |
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |
| EP-1506158-A2 | DIAMINO-FUNCTIONAL CHALCONES | Lica Pharmaceuticals A/S (DK) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097576-A2 | DIAMINO-FUNCTIONAL CHALCONES | LICA PHARMACEUTICALS A/S (DK) | 2003-11-27 | — | — | WO | disclosed |