Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 7/20 | 0.49 |
| ▸ | MAOA | P21397 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.45 |
| ▸ | AR | P10275 | 2/20 | 0.45 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | GUSB | P08236 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3687524 | 1.00 | MAPT (0.55) | MAPTMEN1NPC1MAPK1KMT2A | |
| SCHEMBL3690691 | 0.87 | CXCL12 (0.52) | MAPTMEN1NPC1MAPK1KMT2A | |
| SCHEMBL3686655 | 0.87 | CXCL12 (0.52) | MAPTMEN1NPC1MAPK1KMT2A | |
| SCHEMBL3684549 | 0.83 | MAOB (0.59) | MAPTNPC1KMT2ACXCL12MAOB | |
| SCHEMBL3688379 | 0.83 | MAOB (0.59) | MAPTNPC1KMT2ACXCL12MAOB | |
| SCHEMBL5915662 | 0.83 | CXCL12 (0.56) | MAPTMEN1NPC1MAPK1KMT2A | |
| SCHEMBL5915795 | 0.83 | CXCL12 (0.56) | MAPTMEN1NPC1MAPK1KMT2A | |
| SCHEMBL3684551 | 0.83 | MAOB (0.59) | MAPTNPC1KMT2ACXCL12MAOB | |
| SCHEMBL3693307 | 0.81 | CXCL12 (0.50) | MAPTMEN1NPC1MAPK1KMT2A | |
| SCHEMBL4857406 | 0.81 | BCHE (0.58) | CXCL12MAOBMAOAABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |