Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 6/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4279093 | 0.90 | GPR119 (0.41) | KCNJ1GPR119KMT2AALDH1A1MEN1 | |
| SCHEMBL7602450 | 0.90 | GPR119 (0.41) | KCNJ1GPR119KMT2AALDH1A1MEN1 | |
| SCHEMBL14315928 | 0.90 | GPR119 (0.36) | KCNJ1GPR119KMT2AALDH1A1MEN1 | |
| SCHEMBL7588343 | 0.90 | GPR119 (0.41) | KCNJ1GPR119KMT2AALDH1A1MEN1 | |
| SCHEMBL14296655 | 0.90 | GPR119 (0.36) | KCNJ1GPR119KMT2AALDH1A1MEN1 | |
| SCHEMBL4279095 | 0.90 | GPR119 (0.41) | KCNJ1GPR119KMT2AALDH1A1MEN1 | |
| SCHEMBL16258810 | 0.90 | GPR119 (0.41) | KCNJ1GPR119KMT2AALDH1A1MEN1 | |
| SCHEMBL16242365 | 0.81 | KCNJ1 (0.40) | KCNJ1GPR119KMT2AALDH1A1MEN1 | |
| SCHEMBL3690472 | 0.81 | KCNJ1 (0.40) | KCNJ1GPR119KMT2AALDH1A1MEN1 | |
| SCHEMBL16242397 | 0.81 | KCNJ1 (0.40) | KCNJ1GPR119KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185544-A2 | N-AZACYCLIC SUBSTITUTED PYRROLE, IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES AS AGONISTS OF THE RUP3 OR GPR119 FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS | Metabolex Inc. (US) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009014910-A2 | N-AZACYCLIC SUBSTITUTED PYRROLE, PYRAZOLE, IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES AS AGONISTS OF THE RUP3 OR GPR119 RECEPTOR FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS | METABOLEX, INC. (US) | 2009-01-29 | — | — | WO | disclosed |