SCHEMBL3690265

SCHEMBL3690265

C=C[C@H]1C[C@]1(N)C(=O)OCC

nearest known ligand 0.35

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.35
NPSR1 Q6W5P4 1/20 0.35
ATM Q13315 1/20 0.34
GAA P10253 2/20 0.33
ALOX15 P16050 1/20 0.33
MGAM O43451 1/20 0.33
SI P14410 1/20 0.33
MGAM2 Q2M2H8 1/20 0.33
POLB P06746 1/20 0.33
CYP1A2 P05177 1/20 0.32
TRPA1 O75762 1/20 0.31
LMNA P02545 2/20 0.31
HSD17B10 Q99714 1/20 0.30
ELANE P08246 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2975294 1.00 ALDH1A1 (0.35) ALDH1A1NPSR1ATMGAAALOX15
SCHEMBL1101673 1.00 ALDH1A1 (0.35) ALDH1A1NPSR1ATMGAAALOX15
SCHEMBL374987 1.00 ALDH1A1 (0.35) ALDH1A1NPSR1ATMGAAALOX15
SCHEMBL3799193 1.00 ALDH1A1 (0.35) ALDH1A1NPSR1ATMGAAALOX15
SCHEMBL374714 1.00 ALDH1A1 (0.35) ALDH1A1NPSR1ATMGAAALOX15
SCHEMBL375078 1.00 ALDH1A1 (0.35) ALDH1A1NPSR1ATMGAAALOX15
SCHEMBL12463720 1.00 ALDH1A1 (0.35) ALDH1A1NPSR1ATMGAAALOX15
Hydrochloric Acid SCHEMBL9985470 0.98 ALDH1A1 (0.35) ALDH1A1NPSR1ATMGAAALOX15
Hydrochloric Acid SCHEMBL374713 0.98 ALDH1A1 (0.35) ALDH1A1NPSR1ATMGAAALOX15
Hydrochloric Acid SCHEMBL6117198 0.98 ALDH1A1 (0.35) ALDH1A1NPSR1ATMGAAALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE42164-E1 Hepatitis C inhibitor tri-peptides BOEHRINGER INGELHEIM CANADA LTD. (CA) 2011-02-22 US disclosed
US-RE41894-E1 Hepatitis C inhibitor tri-peptides BOEHRINGER INGELHEIM CANADA LTD. (CA) 2010-10-26 US disclosed
US-RE41356-E1 Hepatitis C inhibitor tri-peptides BOEHRINGER INGELHEIM CANADA LTD. (CA) 2010-05-25 US disclosed
US-RE41356-E1 Hepatitis C inhibitor tri-peptides BOEHRINGER INGELHEIM CANADA LTD. (CA) 2010-05-25 US disclosed
EP-2185524-A1 NOVEL PEPTIDE INHIBITORS OF HEPATITIS C VIRUS REPLICATION Intermune, Inc. (US) 2010-05-19 EP disclosed
EP-1105413-B1 HEPATITIS C INHIBITOR TRI-PEPTIDES BOEHRINGER INGELHEIM CA LTD (CA) 2009-04-29 EP disclosed
EP-2028186-A2 Hepatitis C inhibitor tri-peptides BOEHRINGER INGELHEIM (CANADA) LTD. (CA) 2009-02-25 EP disclosed
WO-2008141227-A1 NOVEL PEPTIDE INHIBITORS OF HEPATITIS C VIRUS REPLICATION INTERMUNE, INC. (US) 2008-11-20 WO disclosed
US-RE40525-E1 Hepatitis C inhibitor tri-peptides BOEHRINGER INGELHEIM (CANADA) LTD. (CA) 2008-09-30 US disclosed
EP-1629000-A4 MACROCYCLIC ISOQUINOLINE PEPTIDE INHIBITORS OF HEPATITIS C VIRUS BRISTOL MYERS SQUIBB CO (US) 2006-11-29 EP disclosed
EP-1629000-A2 MACROCYCLIC ISOQUINOLINE PEPTIDE INHIBITORS OF HEPATITIS C VIRUS Bristol-Myers Squibb Company (US) 2006-03-01 EP disclosed
WO-2004094452-A2 MACROCYCLIC ISOQUINOLINE PEPTIDE INHIBITORS OF HEPATITIS C VIRUS BRISTOL-MYERS SQUIBB COMPANY (US) 2004-11-04 WO disclosed