Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 8/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | ATF4 | P18848 | 3/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3696852 | 0.80 | CDK4 (0.41) | CSF1REGFRAURKAIGF1R | |
| SCHEMBL2203243 | 0.78 | IGF1R (0.38) | ABCB1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL12429650 | 0.78 | IGF1R (0.60) | IGF1R | |
| SCHEMBL3693591 | 0.74 | IGF1R (0.47) | IGF1R | |
| SCHEMBL3762754 | 0.74 | IGF1R (0.48) | CSF1RAURKAIGF1R | |
| SCHEMBL3757450 | 0.73 | ZAP70 (0.52) | CSF1REGFRAURKAIGF1R | |
| SCHEMBL3690895 | 0.71 | IGF1R (0.56) | CSF1RIGF1R | |
| SCHEMBL3752330 | 0.71 | IGF1R (0.44) | IGF1R | |
| SCHEMBL3695065 | 0.70 | IGF1R (0.48) | EGFRIGF1R | |
| SCHEMBL3686747 | 0.69 | IGF1R (0.63) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188292-A1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D]PYRIMIDIN-4-YL) AMINO]BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009020990-A1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D] PYRIMIDIN-4-YL) AMINO] BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |