Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.48 |
| ▸ | CSF1R | P07333 | 6/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3265898 | 0.86 | IGF1R (0.44) | IGF1RMAPK8ABL1BCRHRH3 | |
| SCHEMBL3696852 | 0.83 | CDK4 (0.41) | IGF1RMAPK8CSF1RMAPK10AURKA | |
| SCHEMBL12429491 | 0.77 | IGF1R (0.78) | IGF1RMAPK8 | |
| SCHEMBL2209019 | 0.76 | IGF1R (0.51) | IGF1RMAPK8CSF1RMAPK10ABL1 | |
| SCHEMBL3690348 | 0.74 | ABCB1 (0.37) | IGF1RCSF1RAURKA | |
| SCHEMBL3692759 | 0.73 | IGF1R (0.55) | IGF1RMAPK8CSF1R | |
| SCHEMBL3686747 | 0.73 | IGF1R (0.63) | IGF1RMAPK8MAPK10 | |
| SCHEMBL3805222 | 0.72 | IGF1R (0.48) | IGF1RCSF1RPDE4B | |
| SCHEMBL3757215 | 0.72 | IGF1R (0.48) | IGF1RMAPK8CSF1R | |
| SCHEMBL3764902 | 0.71 | IGF1R (0.44) | IGF1RMAPK8CSF1RMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188292-A1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D]PYRIMIDIN-4-YL) AMINO]BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009020990-A1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D] PYRIMIDIN-4-YL) AMINO] BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |